ArticleFrontiers in medicine2026
Remimazolam-based anesthesia in sepsis patients: a retrospective cohort study of hemodynamic stability and postoperative outcomes.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Patients with abdominal sepsis or septic shock undergoing urgent source-control surgery are highly susceptible to anesthetic-induced hypotension, often requiring vasopressors that may stabilize mean arterial pressure (MAP) but worsen microcirculatory perfusion. This retrospective single-center study evaluated whether remimazolam-based general anesthesia reduces perioperative vasopressor burden and improves hemodynamic stability and postoperative outcomes compared with propofol induction followed by volatile maintenance. Methods: In this study, 220 consecutive Sepsis-3-defined patients who underwent abdominal surgery between January 2021 and June 2025 were analyzed, using a prospectively maintained database. Patients were categorized as propofol/volatile anesthesia (Group C, Results: In a matched cohort (87 per group), VIS at ICU admission was lower with remimazolam ( Conclusion: Remimazolam-based anesthesia was associated with greater hemodynamic stability and reduced postoperative vasopressor needs, translating to lower resource utilization and in-hospital mortality in septic surgical patients undergoing surgery, supporting prospective trials to test causality.
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