ArticleFrontiers in medicine2026
Rechallenge of ruxolitinib after momelotinib-related toxicity in a 74-yo woman with secondary myelofibrosis: a case report.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: In the era of new JAK inhibitors (JAKi), combination therapy, and other targeted therapies, it seems especially important to optimize the treatment options. The rechallenge of a JAKi becomes one of the possibilities, already reported in the literature, the better documented, between ruxolitinib and fedratinib. To date, no case of rechallenge between ruxolitinib and momelotinib (MMB) has been reported. Short report: We present a case of secondary-to-ET myelofibrosis in a 74-year-old female initially treated by high-dose ruxolitinib, switched to momelotinib because of transfusion-dependent anemia, and who developed significant peripheral neuropathy and arthralgias during treatment with momelotinib, unsuccessfully managed by dose reductions, and subsequently re-switched to low-dose ruxolitinib due to the improvement of anemia after MMB and the objective of maintaining symptom control. Conclusion: This case highlights the possibility of revisiting JAKi after momelotinib, depending on therapeutic objectives and to manage adverse effects.
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