ArticleFrontiers in pharmacology2026
Sperm-disrupting activity of a root bark fraction of
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: While Methods: Following extraction and fractionation of authenticated root bark, the resulting extracts were evaluated for cytotoxicity in Vero cells and for disruption of human sperm functions by ascertaining immobilization, revival, viability, cervical mucus penetration and acrosin-related activity. Thereafter, chemical profiling of the most active fraction was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for descriptive annotation. Moreover, Results: The methanolic fraction (KBLM) demonstrated the strongest activity, completely immobilizing sperm, abolishing sperm revival after washing, markedly reducing sperm viability, strongly inhibiting cervical mucus penetration and suppressing acrosin-related activity at 1.62 mg/mL. In a rabbit proof-of-concept experiment, a single intravaginal dose prevented pregnancy at all tested concentrations (3.9, 7.8, and 15.6 mg/mL). Besides, repeated intravaginal exposure for 10 days revealed absent-to-mild cervicovaginal changes. Chemical fingerprinting putatively annotated flavonoid-, tannin-, and phenolic-related features, including catechin, quercetin derivatives, rutin, corilagin, and kaempferol glycosides, as prominent features of KBLM. Conclusion: Our findings have demonstrated the sperm disruption activity of the methanolic fraction of
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