ArticleFrontiers in neurology
Impact of reperfusion on thrombectomy outcomes in patients with pre-stroke disability.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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19 authors.
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Abstract
Background: Mechanical thrombectomy (MT) is frequently performed beyond traditional eligibility criteria, yet the clinical benefits for patients with pre-stroke disability remain uncertain. Methods: We conducted a retrospective multicenter cohort study of patients undergoing MT for anterior circulation large-vessel occlusion stroke across a spectrum of baseline disability (modified Rankin Scale [mRS] 0-4). The primary analysis evaluated the impact of reperfusion success and the 90-day mRS shift within each baseline mRS stratum using ordinal logistic regression adjusted for age, NIHSS, ASPECTS, and occlusion site. Secondary analyses assessed discharge mRS, the effect of first-pass effect (FPE), and whether the etiology of pre-stroke disability modified outcomes. Results: Among 4,840 MT patients, 1,457 (30.1%) had pre-stroke disability (mRS 1-4), with considerable variation in selection practices across centers. In adjusted models, successful reperfusion showed significantly greater odds of improved 90-day mRS for patients with baseline mRS 0-3, with a similar directional benefit in those with mRS 4. No significant interaction between reperfusion and baseline disability regards 90-day mRS was detected ( Conclusion: Successful reperfusion was linked to improved functional outcomes across a wide range of pre-stroke disability levels. Disability etiology did not significantly modify treatment benefits. These findings may support considering MT to appropriately selected patients with baseline disability. Further studies are warranted.
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