Evidence map›Paper›PMID 42459833›Full record

ReviewFrontiers in cell and developmental biology2026

Microprotein, macro-effect: DWORF as a therapeutic strategy in heart failure.

Joseph P Verry, Catherine A Makarewich

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joseph P VerryThe Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Catherine A MakarewichThe Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Funding

Microprotein Regulation of Mitochondrial FunctionR01HL160569 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Catherine A Makarewich · 2022 to 2026
$2.0M
Developing DWORF gene therapy to treat heart failure and muscular dystrophyR01HL171221 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Catherine A Makarewich, Jeffery D Molkentin · 2024 to 2026
$1.8M
NHLBI NIH HHS R01 HL160569NHLBI NIH HHS R01 HL171221
6 · The paper itself

Abstract

Heart failure (HF) is a global health crisis and remains a leading cause of morbidity, mortality, and healthcare expenditure despite substantial advances in pharmacological and device-based therapy. Impaired sarcoplasmic reticulum (SR) Ca

Indexed as

calcium handlingDWORFgene therapyheart failuremicroproteinsarcoplasmic reticulumSERCA2aSTRIT1

Identifiers

PMID42459833
PMCPMC13368986

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.