Evidence map›Paper›PMID 42459831›Full record

ArticleFrontiers in cell and developmental biology2026

Transcription factors ETV4 and ETV5 are required for nephron progenitor cell maintenance, distal nephron development and connection to the collecting system.

Kaitlin Day, Konrad Thorner, Milanya Thumma, Yanzhen Zhang, Evan VordemEsche, William Kuhlman, Aiden Varnell, Anhar Hosawi, Benjamin Hammond, Madison Fraunfelter and 4 more

Abstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kaitlin DayMolecular and Developmental Biology Graduate Program, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Konrad ThornerDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Milanya ThummaDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Yanzhen ZhangDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Evan VordemEscheDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
William KuhlmanDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Aiden VarnellDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Anhar HosawiDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Benjamin HammondDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Madison FraunfelterDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Prashant GaikwadDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Matt KofronDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Franklin D CostantiniDepartment of Genetics and Development, Columbia University, New York City, NY, United States.
Cristina CebrianDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

Funding

Role of Etv4 and Etv5 in the self-renewal and differentiation of nephron progenitorsR01DK132052 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Cristina Cebrian Ligero · 2023 to 2026
$1.8M
NIDDK NIH HHS R01 DK132052
6 · The paper itself

Abstract

The functional unit of the kidney, the nephron, is composed of the renal corpuscle and the renal tubule that includes proximal tubule, loop of Henle, distal and connecting tubule. Each of these segments perform distinct and complementary roles to ensure body homeostasis and urine excretion into the renal collecting system. During nephrogenesis, nephron progenitor cells (NPCs) either self-renew to maintain the progenitor pool or condense and epithelialize into nascent nephrons. Two transcription factors, ETV4 and ETV5 are downstream targets of receptor tyrosine kinase signaling and are known to act redundantly to drive development of the renal collecting system, but their possible role in nephrogenesis has not been elucidated. Here, we show that

Indexed as

cystsembryoEtv4Etv5kidney developmentnephrogenesisnephron progenitor cell (NPC)

Identifiers

PMID42459831
PMCPMC13370208

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.