ArticleFrontiers in cell and developmental biology2026
Transcription factors ETV4 and ETV5 are required for nephron progenitor cell maintenance, distal nephron development and connection to the collecting system.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The functional unit of the kidney, the nephron, is composed of the renal corpuscle and the renal tubule that includes proximal tubule, loop of Henle, distal and connecting tubule. Each of these segments perform distinct and complementary roles to ensure body homeostasis and urine excretion into the renal collecting system. During nephrogenesis, nephron progenitor cells (NPCs) either self-renew to maintain the progenitor pool or condense and epithelialize into nascent nephrons. Two transcription factors, ETV4 and ETV5 are downstream targets of receptor tyrosine kinase signaling and are known to act redundantly to drive development of the renal collecting system, but their possible role in nephrogenesis has not been elucidated. Here, we show that
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