ArticleFrontiers in cell and developmental biology2026
Transcriptome analysis of goat adipose tissue-derived mesenchymal stem cells cultured in variable oxygen conditions.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Oxygen tension influences mesenchymal stem cell biology, but the transcriptional responses of goat adipose tissue-derived mesenchymal stem cells (gADSCs) to different oxygen-exposure conditions remain incompletely understood. Methods: RNA sequencing (RNA-seq) was used to investigate oxygen-dependent transcriptional responses in gADSCs cultured under normoxia (NO), sustained hypoxia (HO), and transient hypoxia (THO). Differentially expressed genes (DEGs), enriched biological processes, and protein-protein interaction networks were analysed. Selected DEGs and hub/bottleneck genes were validated by quantitative reverse transcription PCR (RT-qPCR). Results: The analysis identified condition-associated gene expression changes and candidate pathways related to cell-cycle regulation, DNA repair, extracellular matrix organisation, inflammatory response, pH regulation, angiogenic signalling, and hypoxia-inducible factor-associated adaptation. RT-qPCR validation further revealed differential regulation of hypoxia-inducible factor 1-alpha (HIF1A) and hypoxia-inducible factor 2-alpha (HIF2A), suggesting possible divergence between acute and sustained hypoxic responses. Discussion: These findings provide a transcriptomic resource for understanding oxygen-dependent regulation of gADSCs. However, protein-level validation and functional assays are required to confirm the biological roles of the prioritised genes and assess their relevance to regenerative applications.
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