ArticleFrontiers in nutrition2026
Prognostic value of objective nutritional indices (PNI, CONUT, and HALP) for in-hospital all-cause mortality in surgically treated infective endocarditis: a 14-year retrospective study in a Chinese cohort.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Malnutrition is closely associated with poor clinical outcomes; however, its prognostic value in patients with infective endocarditis (IE) undergoing surgical treatment remains unclear. This study aimed to investigate the association of three objective nutritional indices (PNI, CONUT, and HALP) with in-hospital all-cause mortality in surgically treated patients with IE. Methods: In this retrospective study, clinical data were collected from 450 patients with IE who underwent surgical treatment at Jiangsu Provincial People's Hospital over 14 years. Patients were categorized into a non-survivor group ( Results: The in-hospital all-cause mortality rate in this cohort was 9.33%. Preoperative malnutrition risk was common among patients with IE, with nutritional risk identified in 44.00 and 75.11% of patients according to the PNI and CONUT criteria, respectively. Compared with survivors, non-survivors had significantly poorer baseline nutritional status. After adjustment for confounding factors, each one-unit increase in the PNI was associated with a 7% lower risk of in-hospital all-cause mortality (OR = 0.93, 95% CI: 0.89-0.98, Conclusion: Preoperative malnutrition risk is highly prevalent among patients with IE undergoing surgery and is an independent predictor of postoperative in-hospital all-cause mortality. Routine use of objective nutritional scoring tools, including the PNI, CONUT, and HALP, may improve preoperative risk stratification. Early nutritional assessment and targeted intervention for patients at moderate-to-severe nutritional risk may provide meaningful clinical benefits.
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