Evidence map›Paper›PMID 42459683›Full record

ReviewFrontiers in immunology2026

Hypoxia-driven tumor immune escape: mechanisms and therapeutic opportunities.

Hongran Qin, Shuqiang Yang, Jiawei He, Meijia Zhao, Luqian Zhao, Jingjing Wang, Xiulin Jiang, Xiaowen Chen, Xin Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongran Qin *Department of Nuclear Radiation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Shuqiang Yang *Department of Nuclear Radiation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Jiawei HeDepartment of Nuclear Radiation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Meijia ZhaoDepartment of Nuclear Radiation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Luqian ZhaoDepartment of Nuclear Radiation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Jingjing WangDepartment of Nuclear Radiation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Xiulin JiangCollege of Life Science, University of Chinese Academy of Sciences, Beijing, China.
Xiaowen ChenDepartment of Nuclear Radiation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Xin XuDepartment of Nuclear Radiation, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia is a common feature of solid tumors and a major driver of tumor immune escape. It arises from abnormal tumor vasculature and rapid tumor growth, leading to persistent or fluctuating oxygen deprivation within the tumor microenvironment. Under hypoxic conditions, hypoxia-inducible factors, especially HIF-1α and HIF-2α, activate transcriptional programs that support tumor survival, angiogenesis, glycolytic metabolism, invasion, and therapy resistance. Beyond these tumor-intrinsic effects, hypoxia also reshapes antitumor immunity by suppressing CD8

Indexed as

NeoplasmsTumor EscapeAnimalsHost-Directed TherapyHumansHypoxia-Inducible Factor 1, alpha SubunitImmunotherapyMetabolic ReprogrammingSignal TransductionT-Cell ExhaustionTumor MicroenvironmentHypoxia-Inducible Factor 1, alpha Subunitcancer immunotherapyHIF-1αhypoxiaimmune checkpointsimmune escapemetabolic reprogrammingmyeloid-derived suppressor cellsRNA epitranscriptomics

Identifiers

PMID42459683
PMCPMC13369166

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.