Evidence map›Paper›PMID 42459658›Full record

ReviewFrontiers in immunology2026

The mitochondrial logic of inflammaging: how energy imbalance drives fibroblast SASP and tissue-specific aging.

Yu Huan, Qiqi Wang, Rongkaixuan Fang, Yue Sun, Meiya Suo, Chenghong Cao, Shuya Zhang, Lan A, Wenzhou Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yu HuanDepartment of Periodontology, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
Qiqi WangDepartment of Periodontology, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
Rongkaixuan FangJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
Yue SunDepartment of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
Meiya SuoDepartment of Periodontology, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
Chenghong CaoDepartment of Periodontology, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
Shuya ZhangJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
Lan ADepartment of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.
Wenzhou XuDepartment of Periodontology, Hospital of Stomatology, Jilin University, Changchun, Jilin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The conversion of metabolic disequilibrium into chronic inflammatory signaling represents a central and actively investigated question in ageing biology. Among stromal cells, fibroblasts are key effectors of tissue remodeling and inflammation, acquiring a senescence-associated secretory phenotype (SASP) that sustains age-related pathology. Here, we delineate a mechanistic framework in which disruption of energy homeostasis drives mitochondrial dysfunction, innate immune activation, and SASP secretion. Mitochondria act as metabolic sentinels that sense energetic stress through altered AMP/ATP and NAD

Indexed as

AgingEnergy MetabolismFibroblastsInflammationMitochondriaSenescence-Associated Secretory PhenotypeAnimalsCellular SenescenceDNA, MitochondrialHumansImmunity, InnateInflammasomesMetabolic ReprogrammingSignal TransductionDNA, MitochondrialInflammasomescellular senescencefibroblastsinflammaginginnate immune signalingmetabolic reprogrammingmitochondrial dysfunctionsenescence-associated secretory phenotype (SASP)

Identifiers

PMID42459658
PMCPMC13368628

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.