ArticleFrontiers in pediatrics2026
Maternal immunization status and SARS-CoV-2 antibody transfer to neonates at birth.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Introduction: Following the COVID-19 pandemic, hybrid immunity, arising from a combination of SARS-CoV-2 infection and vaccination, is widespread across populations, yet the dynamics of maternal antibody transfer to neonates in this context are not fully characterized. Methods: We conducted a cohort study of 117 pregnant women, assessing IgG antibodies against SARS-CoV-2 nucleoprotein and receptor-binding domain (RBD) in maternal, umbilical cord, and neonatal blood at delivery. Results: Using ELISA and pseudo virus neutralization assays, we found that 95% of mothers had detectable IgG, with 87% of neonates acquiring antibodies trans placentally. Hybrid immunity, detected in 65.5% of mothers, was associated with higher anti-RBD IgG levels in newborns compared to natural or vaccination-induced immunity alone. Neutralizing antibodies correlated positively with IgG titers, with umbilical cord samples showing the highest neutralization capacity. Discussion: These findings suggest that combined natural infection and vaccination in mothers enhance passive immunity in neonates, potentially improving early-life protection against SARS-CoV-2.
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