ArticleDusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi2024
Retinal abnormalities and their relationship with social cognition in patients with schizophrenia and their healthy siblings.
Article in Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Association Between Optical Coherence Tomography Angiography (OCTA)-Based Retinal Vascular Densities and Empathy in Young Adults.Bioengineering (Basel, Switzerland) · 2025Article
- Retinal biomarkers in schizophrenia spectrum disorders: evidence and implications for the neurodevelopmental and neurodegenerative models.Frontiers in medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to investigate retinal abnormalities and their relationship with social cognitive function, and to assess whether retinal changes could be observed in the healthy siblings of patients with schizophrenia in a similar manner, suggesting their potential as an endophenotype. Method: The study included 28 patients with schizophrenia, 28 of their siblings, and 28 healthy control subjects. Social cognition tests were administered, and measurements of the retinal nerve fiber layers (RNFL), ganglion cell layer plus inner plexiform layer (GCL+IPL), and cup volumes were obtained using optical coherence tomography (OCT). Results: Analyses revealed no differences between the groups in RNFL thickness. The cup volume was significantly larger in both eyes of the patient group compared to the control group. The mean thickness of the GCL+IPL in the left eye was significantly lower in the patient group compared to the healthy control group, with a similar difference also observed between the siblings of patients and the control group. A statistically significant difference was found among all groups in the total scores of social cognition tests. A weak correlation was identified between retinal layer thicknesses and social cognition test scores in both the patient and sibling groups. Conclusion: These findings suggest that GCL+IPL thickness can be a useful endophenotype for the early diagnosis of schizophrenia. While retinal changes do not predict cognitive symptoms in patients with schizophrenia, they may play an important role in identifying high-risk groups.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.