ArticleBrain communications2026
Interhemispheric connectivity measured with transcranial magnetic stimulation and EEG as an objective marker of cognitive risk.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cognitive impairment is a common complaint in older adults, yet its evaluation relies largely on subjective reports and cognitive tests with variable sensitivity. Identifying objective neurophysiological markers of brain function may enable earlier detection and more individualized intervention strategies. A total of 454 participants (mean age 61.4 ± 7.5 years; 45.3% females) underwent bilateral dorsolateral prefrontal cortex (DLPFC) transcranial magnetic stimulation (TMS)-EEG with the Delphi-MD system, alongside cognitive testing (Monreal Cognitive Assessment [MoCA] and NeuroTrax domains: memory, attention and executive function) and emotional inventories. Linear regression tested demographic and clinical predictors of cognition. K-means clustering identified cognitive subgroups, with between-cluster interhemispheric connectivity (IHC) differences assessed by Mann-Whitney U-tests. Binary logistic regression with 5000 bootstrap resamples evaluated IHC as a predictor of cognitive cluster membership. Older age was associated with lower MoCA (worse) (
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