ArticleFrontiers in cellular and infection microbiology2026
Neutrophil kinetics of
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Neutrophil migration is a hallmark of acute inflammation and represents a key component of the early innate immune response to bacterial infection. We previously demonstrated the ability to track neutrophil movement from bone marrow to blood and subsequently to tissues using 5-bromo-2'-deoxyuridine (BrdU) pulse labeling in healthy adult rhesus macaques ( Methods: In this study, we extend our analyses to investigate the kinetics of neutrophil movement during acute inflammatory responses using Results: BrdU labeling revealed significant neutrophil consumption from blood into tissues and replenishment from bone marrow to blood as early as three days post-challenge, with a transient increase in neutrophil counts in blood at day nine post-challenge. Moreover, the extent of neutrophil kinetic changes correlated with the doses of Discussion: These findings suggest that BrdU-labeled neutrophil kinetics provide valuable insights into neutrophil dynamics
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