ArticleFrontiers in oncology2026
Occult clival chordoma initially unrecognized on MRI presenting with cerebrospinal fluid rhinorrhea: a case report.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Cerebrospinal fluid (CSF) rhinorrhea most frequently results from traumatic or iatrogenic skull base disruption. In contrast, tumor-induced spontaneous CSF leaks and the subsequent development of purulent meningitis (PM) are relatively rare and pose significant diagnostic challenges.Case Presentation: A 39-year-old man presented with acute headache and fever following a two-month history of intermittent, clear unilateral rhinorrhea. Lumbar puncture confirmed PM, and brain magnetic resonance imaging (MRI) revealed left lateral ventricular empyema but no definitive skull-base mass. After achieving clinical stability with a two-week course of targeted antibiotics, the patient underwent endoscopic CSF fistula repair. Intraoperatively, a clival lesion was encountered; histopathological examination (characterized by physaliferous cells and brachyury positivity) confirmed the diagnosis of chordoma. Conclusion: This case suggests that persistent spontaneous CSF rhinorrhea can be the initial manifestation of an occult skull-base tumor, even in the absence of clear findings on preoperative MRI. In patients with CSF leak complicated by meningitis, management must prioritize infection control while concurrently pursuing a thorough etiologic workup and timely surgical intervention to address both the fistula and any underlying neoplasm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.