Evidence map›Paper›PMID 42459198›Full record

ArticleClinical psychological science : a journal of the Association for Psychological Science2023

Connectivity patterns evoked by fearful faces demonstrate reduced flexibility across a shared dimension of adolescent anxiety and depression.

N A Hubbard, R P Auerbach, V Siless, N Lo, I R Frosch, D E Clark, R Jones, R Kremens, M Pinaire, F Vaz De Souza and 8 more

Abstract read
In one paragraph

Article in Clinical psychological science : a journal of the Association for Psychological Science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

N A HubbardMassachusetts Institute of Technology, Department of Brain and Cognitive Science and McGovern Institute for Brain Research, Cambridge, MA.
R P AuerbachColumbia University, Department of Psychiatry, New York, NY.
V SilessMassachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA.
N LoMassachusetts Institute of Technology, Department of Brain and Cognitive Science and McGovern Institute for Brain Research, Cambridge, MA.
I R FroschMassachusetts Institute of Technology, Department of Brain and Cognitive Science and McGovern Institute for Brain Research, Cambridge, MA.
D E ClarkUniversity of Nebraska-Lincoln, Department of Psychology, Lincoln, NE.
R JonesMassachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA.
R KremensMcLean Hospital, Center for Depression, Anxiety, and Stress Research, Belmont, MA.
M PinaireMcLean Hospital, Center for Depression, Anxiety, and Stress Research, Belmont, MA.
F Vaz De SouzaMassachusetts General Hospital, Department of Psychiatry, Boston, MA.
S S GhoshMassachusetts Institute of Technology, Department of Brain and Cognitive Science and McGovern Institute for Brain Research, Cambridge, MA.
A HeninMassachusetts General Hospital, Department of Psychiatry, Boston, MA.
S G HofmannBoston University, Department of Psychological and Brain Sciences, Boston, MA.
D A PizzagalliMcLean Hospital, Center for Depression, Anxiety, and Stress Research, Belmont, MA.
I M RossoMcLean Hospital, Center for Depression, Anxiety, and Stress Research, Belmont, MA.
A YendikiMassachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA.
S Whitfield-GabrieliMassachusetts Institute of Technology, Department of Brain and Cognitive Science and McGovern Institute for Brain Research, Cambridge, MA.
Jde GabrieliMassachusetts Institute of Technology, Department of Brain and Cognitive Science and McGovern Institute for Brain Research, Cambridge, MA.

Funding

Testing the Efficacy of Ibudilast to Attenuate Meth-seeking and Associated Synaptic Inflammation at the Synapse (TEAMS)P20GM130461 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI SCOTT BARRETT · 2019 to 2026
$20.6M
Resource DiscoveryP41EB019936 · NIBIB · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Yaroslav O Halchenko · 2016 to 2026
$15.2M
CONNECTOME 2.0: DEVELOPING THE NEXT GENERATION HUMAN MRI SCANNER FOR BRIDGING STUDIES OF THE MICRO-, MESO- AND MACRO-CONNECTOMEU01EB026996 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BASSER, PETER J., HUANG, SUSIE YI · 2018 to 2022
$14.2M
Neuroimaging Studies of Reward Processing in DepressionR37MH068376 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI Diego A Pizzagalli · 2016 to 2026
$7.4M
Connectomes Related to Anxiety and Depression in AdolescentsU01MH108168 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIELI, JOHN, WHITFIELD-GABRIELI, SUSAN · 2015 to 2019
$4.6M
Social Processing Deficits in Remitted Adolescent DepressionR01MH119771 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI AUERBACH, RANDY PATRICK, SHANKMAN, STEWART AARON · 2020 to 2025
$3.7M
Multimodal imaging of hippocampal-cortical networks and mechanisms of trauma-related intrusionsR01MH120400 · NIMH · MCLEAN HOSPITAL · PI ROSSO, ISABELLE M · 2019 to 2023
$3.3M
Nipype: Dataflows for Reproducible Biomedical ResearchR01EB020740 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GHOSH, SATRAJIT SUJIT · 2016 to 2019
$2.7M
Toward Outcome Measurement of Anxiety in Youth with Autism Spectrum DisordersR01MH099021 · NIMH · YALE UNIVERSITY · PI SCAHILL, LAWRENCE D. · 2012 to 2015
$2.7M
Multi level Analysis of Positive Valence Systems Across Mood DisordersR01MH101521 · NIMH · MCLEAN HOSPITAL · PI PIZZAGALLI, DIEGO A · 2013 to 2016
$2.1M
1/2-Yoga For Generalized Anxiety DisorderR01AT007257 · NCCIH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HOFMANN, STEFAN G. · 2013 to 2017
$2.0M
A Storage Area Network for Structural and Functional Image AnalysisS10RR023401 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2009 to 2009
$2.0M
NCCIH NIH HHS R01 AT007257NCRR NIH HHS S10 RR019307NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NIBIB NIH HHS P41 EB019936NIBIB NIH HHS R01 EB020740NIBIB NIH HHS R01 EB021265NIBIB NIH HHS U01 EB026996NIGMS NIH HHS P20 GM130461NIMH NIH HHS F32 MH114525NIMH NIH HHS L30 MH117669NIMH NIH HHS R01 MH096987NIMH NIH HHS R01 MH099021NIMH NIH HHS R01 MH101521NIMH NIH HHS R01 MH119771NIMH NIH HHS R01 MH120400NIMH NIH HHS R37 MH068376NIMH NIH HHS R56 MH121426NIMH NIH HHS U01 MH108168
6 · The paper itself

Abstract

Adolescents experiencing anxiety or depression exhibit cognitive biases favoring the processing of negative emotional information. It remains unknown whether common neurobiological processes underlie these biases across anxiety and depression. Here, brain imaging was acquired from typical, anxious, and depressed adolescents during an emotional interference task. Functional connectivity patterns were assessed while adolescents were cued to attend to or ignore faces. Results revealed a shared dimension of anxious and depressive symptoms was associated with reduced changes in connectivity patterns between conditions wherein adolescents needed to ignore or attend to fearful faces. These findings were exclusive to fearful faces and only observed for functional connections with a primary face-representation area (fusiform gyrus). Results suggested a failure to flexibly adapt communication patterns with sensory representation areas in the presence of negative emotional information, which may reflect a common neurobiological mechanism explaining biases favoring such information shared amongst adolescent anxiety and depression.

Indexed as

ADOLESCENT DEVELOPMENTANXIETYCOGNITIVE BIASDEPRESSION

Identifiers

PMID42459198
PMCPMC13372253

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.