Evidence map›Paper›PMID 42459125›Full record

ArticleMolecular nutrition & food research2026

The Ganoderma atrum Polysaccharide PSG-1 Attenuates Acrylamide-Induced Hepatotoxicity by Modulating the FXR-FGF15-Mediated Gut-Liver Axis.

Shiyu Chen, Chunchao Nie, Yuting Wang, Ziyan Guo, Kaichang Zhao, Qiang Yu, Jianhua Xie, Yi Chen

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In one paragraph

Article in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Shiyu ChenState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, People's Republic of China.
Chunchao NieState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, People's Republic of China.
Yuting WangState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, People's Republic of China.
Ziyan GuoJiangxi Province Science and Technology Infrastructure Center, Nanchang, People's Republic of China.
Kaichang ZhaoState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, People's Republic of China.
Qiang YuState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, People's Republic of China.
Jianhua XieState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, People's Republic of China.
Yi ChenState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, People's Republic of China.

Funding

National Key R&D Program of China 2024YFF1106100Natural Science Foundation of Jiangxi Province 20242BAB20329Science and Technology Innovation Base Construction Project of Jiangxi Province 20232BCD44004
6 · The paper itself

Abstract

Acrylamide (AA), a widespread food-processing contaminant, induces intestinal injury and hepatotoxicity by disrupting barrier function, redox balance, bile acid metabolism, and gut microbial ecology. This study examined the protective benefits of Ganoderma atrum polysaccharide (PSG-1), focusing on the gut-liver axis. PSG-1 reduced serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bile acid (TBA) levels and improved liver histology. It also restored antioxidant defense by enhancing superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities while lowering malondialdehyde (MDA). At the intestinal level, PSG-1 alleviated barrier disruption and reversed gut dysbiosis, restoring Lactobacillus abundance. This microbial modulation coincided with reactivation of the farnesoid X receptor (FXR)/fibroblast growth factor 15 (FGF15) pathway, which normalized hepatic cholesterol 7α-hydroxylase (CYP7A1) expression and improved bile acid homeostasis. PSG-1 also corrected retinol metabolism disorders by reducing lecithin-retinol acyltransferase (LRAT) and restoring retinol-binding protein 4 (RBP4). These results demonstrate that PSG-1 protects against AA-induced intestinal and hepatic injury through coordinated regulation of oxidative stress, gut microbiota composition, and FXR-mediated bile acid signaling along the gut-liver axis.

Indexed as

AcrylamideChemical and Drug Induced Liver InjuryFibroblast Growth FactorsGanodermaLiverPolysaccharidesReceptors, Cytoplasmic and NuclearAnimalsAntioxidantsBile Acids and SaltsGastrointestinal MicrobiomeMaleOxidative StressReceptor, Farnesoid X-ActivatedAcrylamideAntioxidantsBile Acids and SaltsFibroblast Growth FactorsPolysaccharidesReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and Nuclearacrylamidebile acid metabolismFXR‐FGF15 signaling pathwayGanoderma atrum polysaccharidegut microbiotaintestinal barrierLactobacillus rhamnosus GGretinol metabolism

Identifiers

PMID42459125
PMCPMC13373629

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.