Evidence map›Paper›PMID 42458889›Full record

ArticleArchiv der Pharmazie2026

Total Synthesis of Marine Natural Product Sunshinamide via Macrolactonization.

Yi Lu, Yuanmu Zhang, Hanqi Wang, Ya Gao, Ahmed Sabt, Wei Zhang, Xinsheng Lei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archiv der Pharmazie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yi LuSchool of Pharmacy, Fudan University, Shanghai, China.
Yuanmu ZhangSchool of Pharmacy, Fudan University, Shanghai, China.
Hanqi WangSchool of Pharmacy, Fudan University, Shanghai, China.
Ya GaoShanghai Forxine Pharmaceutical Co. Ltd., Shanghai, China.
Ahmed SabtChemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Cairo, Egypt.
Wei ZhangSchool of Pharmacy, Fudan University, Shanghai, China.
Xinsheng LeiSchool of Pharmacy, Fudan University, Shanghai, China.

Funding

National Natural Science Foundation of China 82173734Qingdao Marine Science and Technology Center 2022QNLM030003-2Science and Technology Commission of Shanghai Municipality 202040114Shanghai Municipal Health Commission 20490740500
6 · The paper itself

Abstract

A new approach for the synthesis of marine natural product Sunshinamide has been developed, featuring macrolactonization as a key step. The important synthetic strategy is to first construct the unique 8-membered cyclic dithiazocane in the earlier stage and finally carry out macrolactonization according to Shiina's method. Compared with the reported macrolactamization of a linear precursor, the macrolactonization bearing the cyclic dithiazocane scaffold resulted in a lower macrocyclization yield, implying that the cyclic dithiazocane might not offer a more favorable conformational constraint for macrocyclization.

Indexed as

Biological ProductsDepsipeptidesCyclizationMolecular StructureBiological ProductsDepsipeptidescyclic dithiazocanedepsipeptidesmarine natural productSunshinamidesynthesis

Identifiers

PMID42458889
PMCPMC13373492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.