ArticleBioMed research international2026
Electrophysiological Modeling and Molecular Dynamics Simulations of Cardiac Sodium Channels in Brugada Syndrome.
Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Electrophysiological Modeling and Molecular Dynamics Simulations of Cardiac Sodium Channels in Brugada Syndrome.BioMed research international · 2026Article
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2 authors.
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Abstract
Brugada syndrome (BrS) is a rare but potentially fatal genetic cardiac disorder, primarily caused by mutations in sodium and potassium ion channels, leading to ventricular arrhythmias and sudden cardiac death. Despite advances in computational modeling, the precise effects of ionic environment and channel kinetics on BrS-related action potentials remain incompletely understood. In this study, we developed a flexible electrophysiological model of cardiac sodium channels using a modifiable Richards activation function to simulate major BrS phenotypes and optimized the shape parameter (h) using particle swarm optimization (PSO). In parallel, molecular dynamics (MD) simulations were performed to analyze Na
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