Evidence map›Paper›PMID 42458730›Full record

ArticleGut microbes2026

Multi-omic modelling of body mass index response to a dietary weight loss intervention.

Emily N Yeo, Ashley W Scadden, Zachary T Caterer, Kristen J Sutton, Iain R Konigsberg, Joanne B Cole, Elizabeth M Litkowski, Zhaoxing Pan, Catherine A Lozupone, Danielle M Ostendorf and 7 more

Abstract read
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Emily N YeoDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, USA.ORCID 0000-0003-2113-0077
Ashley W ScaddenDepartment of Biomedical Informatics, University of Colorado Anschutz, Aurora, USA.ORCID 0000-0001-7603-1442
Zachary T CatererDepartment of Biomedical Informatics, University of Colorado Anschutz, Aurora, USA.ORCID 0000-0001-9019-0730
Kristen J SuttonDepartment of Biomedical Informatics, University of Colorado Anschutz, Aurora, USA.ORCID 0000-0002-3704-3560
Iain R KonigsbergDepartment of Biomedical Informatics, University of Colorado Anschutz, Aurora, USA.ORCID 0000-0001-7356-100X
Joanne B ColeDepartment of Biomedical Informatics, University of Colorado Anschutz, Aurora, USA.ORCID 0000-0001-9520-2788
Elizabeth M LitkowskiDepartment of Neurology, University of Michigan, Ann Arbor, USA.ORCID 0000-0002-7079-696X
Zhaoxing PanDepartment of Pediatrics, University of Colorado Anschutz, Aurora, USA.ORCID 0000-0002-9319-2501
Catherine A LozuponeDepartment of Biomedical Informatics, University of Colorado Anschutz, Aurora, USA.ORCID 0000-0003-4786-7202
Danielle M OstendorfDepartment of Kinesiology, Recreation, and Sports Studies, University of Tennessee, Knoxville, USA.ORCID 0000-0002-3923-5726
Paul S MacLeanDepartment of Medicine, University of Colorado Anschutz, Aurora, USA.ORCID 0000-0002-1123-6612
Edward L MelansonDepartment of Medicine, University of Colorado Anschutz, Aurora, USA.ORCID 0000-0001-9151-9745
Daniel H BessesenDepartment of Medicine, University of Colorado Anschutz, Aurora, USA.ORCID 0000-0002-8242-9198
Sarah J BorengasserDepartment of Pediatrics, Diabetes & Endocrinology, University of Oklahoma Health Campus, USA.ORCID 0000-0002-9984-0178
Ethan M LangeDepartment of Biomedical Informatics, University of Colorado Anschutz, Aurora, USA.ORCID 0000-0001-7075-4287
Victoria A CatenacciDepartment of Medicine, University of Colorado Anschutz, Aurora, USA.ORCID 0000-0001-9723-3748
Maggie A StanislawskiDepartment of Biomedical Informatics, University of Colorado Anschutz, Aurora, USA.ORCID 0000-0001-7768-8868

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BRYAN C BERGMAN · 1995 to 2026
$32.6M
Suppression of ERalpha in Hematopoietic Stem Cell-Derived Adipocytes Increases Adiposity via Kynurenine and the Aryl Hydrocarbon ReceptorU54AG062319 · NIA · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 2018 to 2026
$13.5M
Computational Bioscience Program Training GrantT15LM009451 · NLM · UNIVERSITY OF COLORADO DENVER · PI Katherina Kechris-Mays, Arjun Krishnan · 2007 to 2026
$11.7M
NIDDK National Research Service Award (NRSA) T32 Diversity Administrative SupplementT32DK007658 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Kristen Elizabeth Boyle, Ihuoma U Eneli · 1991 to 2026
$6.0M
Novel dietary interventions for reducing obesity-associated breast cancerR01CA258766 · NCI · UNIVERSITY OF COLORADO DENVER · PI VICTORIA A CATENACCI, Peter Kabos · 2022 to 2026
$3.1M
The Contribution of Omic Profiles to Weight Loss and ObesityK01HL157658 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Maggie A Stanislawski · 2022 to 2026
$794k
NCI NIH HHS R01 CA258766NHLBI NIH HHS K01 HL157658NIA NIH HHS U54 AG062319NIDDK NIH HHS P30 DK048520NIDDK NIH HHS T32 DK007658NLM NIH HHS T15 LM009451
6 · The paper itself

Abstract

Obesity is a multifactorial condition, and there is wide heterogeneity in responses to weight loss interventions. Although it remains challenging, modeling responses to weight loss interventions can help tailor treatments, increase weight loss success, or improve our understanding of underlying pathophysiology. We leveraged multi-omic (genetics; gut microbiota: taxonomy, inferred gene pathways and metabolite dynamics; blood metabolomics) and clinical data (e.g., lipids, blood glucose) from a 12-month behavioral weight loss trial of adults (

Indexed as

Body Mass IndexObesityOverweightWeight LossAdultFemaleGastrointestinal MicrobiomeHumansMaleMetabolomicsMiddle AgedMultiomicsBehavioral interventionMetabolomicsMicrobiomeObesityWeight loss

Identifiers

PMID42458730
PMCPMC13378728

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.