Evidence map›Paper›PMID 42458589›Full record

ReviewAdvances in simulation (London, England)2026

Simulator development using natural language: clinician-led innovation through artificial intelligence.

Federico Lorenzo Barra, Serena Ricci, Edoardo Moro, Jiří Travěnec, Alessandro Costa, Luca Carenzo, Giovanna Rodella, Rosanna Vaschetto

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in simulation (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Federico Lorenzo BarraDepartment of Anesthesiology and Intensive Care Medicine, Azienda Ospedaliero-Universitaria "Maggiore della Carità", Novara, Italy.
Serena RicciDepartment of Informatics, Bioengineering, Robotics, and Systems Engineering, University of Genova, Genova, Italy.
Edoardo MoroDepartment of Anesthesiology and Intensive Care Medicine, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
Jiří TravěnecDepartment of Simulation Medicine, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Alessandro CostaSIMNOVA - Centro Interdipartimentale di Didattica Innovativa e di Simulazione in Medicina e Professioni Sanitarie, Università del Piemonte Orientale, Novara, Italy.
Luca CarenzoDepartment of Anesthesia and Intensive Care Medicine, IRCCS Humanitas Research Hospital, Via Manzoni 56, Milano, Rozzano, 20089, Italy. luca.carenzo@gmail.com.ORCID http://orcid.org/0000-0002-4646-2660
Giovanna RodellaSIMNOVA - Centro Interdipartimentale di Didattica Innovativa e di Simulazione in Medicina e Professioni Sanitarie, Università del Piemonte Orientale, Novara, Italy.
Rosanna VaschettoDepartment of Anesthesiology and Intensive Care Medicine, Azienda Ospedaliero-Universitaria "Maggiore della Carità", Novara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHealthcare simulation training faces significant barriers due to the "clinician-developer gap," where educators lack programming expertise to create customized digital simulators. Natural Language-Driven Development (NLDD) is an emerging paradigm that enables clinicians to develop educational technology through conversational artificial intelligence interfaces.

methodsWe implemented NLDD methodology to develop Open Vent Sim, a comprehensive mechanical ventilation simulator designed to replace anesthesia machines and ventilators in educational contexts lacking dedicated equipment. A multidisciplinary team comprising anesthesiologists, residents, a research nurse, IT, and biomedical engineers collaborated using Google AI Studio to iteratively create a web-based application through natural language prompts. Development proceeded through conversational cycles in which clinical requirements were translated into functional code via large language model assistance.

resultsOpen Vent Sim was successfully developed in about 40 h over two weeks, featuring three simulation environments: anesthesia workstation, ICU ventilator, and high-flow oxygenation systems. The simulator incorporates physiological patient profiles (normal, ARDS, COPD) with dynamic compliance calculations and realistic waveform generation. Clinical validation was achieved through the integration of continuous resident feedback during iterative development. The application was successfully implemented in SimZone 1 as an interactive skill trainer and in SimZone 2 for team-based clinical scenarios during formal anesthesia and critical care education. Significant technical adaptation was required to transform the AI-generated prototype into a production-ready application.

conclusionsNLDD demonstrates the potential to democratize the creation of educational technology by empowering clinical domain experts to develop sophisticated simulation tools without traditional programming expertise. This approach addresses resource limitations while maintaining clinical authenticity, though professional technical oversight remains essential for production-ready implementations.

Indexed as

Artificial IntelligenceEducational TechnologyHealthcare InnovationMechanical VentilationMedical EducationNatural Language ProgrammingOpen Source SoftwareSimulation-Based Learning

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.