Evidence map›Paper›PMID 42458491›Full record

ArticleDiagnostic pathology2026

Identification of factors associated with intraductal carcinoma of the prostate.

Motoki Yamagishi, Casey M Phan, Yoshihiro Nakagami, Akiko Tokunaga, So Murai, Toshiko Yamochi, Kazuhiko Oshinomi, Masakazu Nagata, Takashi Fukagai

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In one paragraph

Article in Diagnostic pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Motoki YamagishiDepartment of Urology, Showa Medical University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan. yamagishi@med.showa-u.ac.jp.ORCID https://orcid.org/0000-0003-4505-7513
Casey M PhanQueen's Medical Center, Pathology, Honolulu, United States.
Yoshihiro NakagamiDepartment of Urology, Showa Medical University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.
Akiko TokunagaJohn A. Burns School of Medicine, Department of Pathology, University of Hawaii at Manoa, Honolulu, United States.
So MuraiDepartment of Pathology, Showa Medical University School of Medicine, Tokyo, Japan.
Toshiko YamochiDepartment of Pathology, Showa Medical University School of Medicine, Tokyo, Japan.
Kazuhiko OshinomiDepartment of Urology, Showa Medical University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.
Masakazu NagataDepartment of Urology, Showa Medical University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.
Takashi FukagaiDepartment of Urology, Showa Medical University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProstate cancer is a common malignancy. Intraductal carcinoma of the prostate (IDCP) is associated with poor prognosis, but is underreported in certain geographic regions. The presence of IDCP is recently recognized as an independent prognosticatior of poor prognosis. We aim to identify factors associated with IDCP on radical prostatectomy specimens to aid in more accurate diagnosis of IDCP.

methodsA retrospective study was conducted on specimens from Showa Medical University Hospital (Japan) and Queen's Medical Center (Hawaii) from April 2020 to March 2024. Clinical data included age, PSA, and race; pathological data included GS, GG, and factors indicated the extent of cancer (EPE, RM, LVI, PNI, SVI). IDCP was diagnosed morphologically; equivocal lesions underwent basal cell IHC. Statistical analyses identified factors associated with IDCP.

resultsAmong 279 cases, IDCP was found in 70 (25.1%). The IDCP-positive group had higher PSA levels (14.2 vs. 10.7 ng/ml, p = 0.048). Univariate and Multivariate analyses identified GS (OR: 16.41, p < 0.001), EPE (OR: 2.36, p = 0.02), and PNI(OR: 2.57, p = 0.02) remained independently associated.

conclusionHigh grade (GS ≥ 8), EPE, and PNI serve as practical pathological triggers to scrutinize ducts and apply basal-cell IHC, which may reduce under-recognition of IDCP in RP specimens.

Indexed as

Carcinoma, DuctalCarcinoma, Intraductal, NoninfiltratingProstatic NeoplasmsAgedHumansMaleMiddle AgedNeoplasm GradingPrognosisProstatectomyProstate-Specific AntigenRetrospective StudiesRisk FactorsProstate-Specific AntigenAccociated factorsIntraductal carcinoma of the prostateProstate cancerProstatectomy

Identifiers

PMID42458491
PMCPMC13659963

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.