ArticleBMC gastroenterology2026
Association between the TyG/HDL-C ratio and non-alcoholic fatty liver disease: a single-centre retrospective study.
Article in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTriglyceride-glucose index to high density lipoprotein cholesterol ratio (TyG/HDL-C ratio) is a novel surrogate indicator for insulin resistance. However, the predictive value of TyG/HDL-C ratio for the presence of non-alcoholic fatty liver disease (NAFLD) remains unclear. In this study, we aimed to investigate the relationship between TyG/HDL-C ratio and NAFLD in health check-up populations from China.
methodsA total of 1592 participants aged ≥ 40 years were included. Patients were divided into three groups according to the tertiles of TyG/HDL-C ratio, the indicators were compared among the three groups. The univariate linear regression model and the multivariate models were performed to investigate the association between TyG/HDL-C ratio and NAFLD. Smoothed curve fit analysis was used to explore the linear or non-linear relationship between TyG/HDL-C ratio and NAFLD. The modification and interaction of subgroups were inspected by the likelihood ratio test.
resultsAfter adjusting for confounders, there was a non-linear relationship between TyG/HDL-C ratio and NAFLD. The inflection point was 10.0. When TyG/HDL-C ratio < 10.0, the relationship was as (OR = 1.23, 95%CI: 1.13 to 1.33, P < 0.0001) ,while when ≥ 10.0, the association was not statistically significant (OR = 0.89, 95%CI: 0.80 to 1.00, P = 0.0553). Subgroup analysis suggested that no significant interactions were observed. TyG/HDL-C ratio presented moderate discriminative capacity for NAFLD.
conclusionsWe discovered that there was a non-linear positive association between TyG/HDL-C ratio and NAFLD. When TyG/HDL-C ratio was less than 10.0, a positive association was found.
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