ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026
Circulating T-cell phenotypes are influenced by prior Staphylococcus aureus exposure in hemodialysis patients.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Staphylococcus aureus bloodstream infections are a significant risk for hemodialysis patients, who would significantly benefit from a preventative vaccine. To-date S. aureus vaccine trials have failed, in part due to lack of consideration of pre-existing immune imprints in relevant patient cohorts. Using a machine learning algorithm this study revealed, prior S. aureus exposure in a cohort of 180 hemodialysis patients, was associated with an increase in circulating S. aureus antigen-specific exTh17 cells and reduced antigen-specific IL-10 producing CD4 cells and circulating NK cells and Vδ2 cells. It provides novel insights into pre-existing S. aureus immunity in hemodialysis patients that could inform next generation vaccine development.
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