Evidence map›Paper›PMID 42458155›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2026

Acetylcholinesterase inhibiting withanolides from Curvularia pseudobrachyspora, an endophytic fungus of Withania somnifera (L.) Dunal.

Anu Gupta, M Vasundhara

Abstract read
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anu GuptaDepartment of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, Punjab, 147004, India.
M VasundharaDepartment of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, Punjab, 147004, India. mvasundhara@thapar.edu.ORCID http://orcid.org/0000-0002-7302-4869

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease is the most prominent neurological illness, and the present investigation sets out to determine the impact of bioactive substances from endophytic fungi on acetylcholinesterase (AChE) inhibition. Medicinal plant Withania somnifera (L.) Dunal was used to isolate endophytic fungi, and WSE42 (out of 49 isolates) exhibited higher AChE inhibition (78.57%) and free radical scavenging activity (82.47%) in its methanolic crude extract. WSE42 was identified as Curvularia pseudobrachyspora (accession number-PP837926), and among all the fractions collected by column chromatography, two fractions (F3 and F4) exhibited potential for AChE inhibition with IC

Indexed as

AcetylcholinesteraseAscomycotaCholinesterase InhibitorsEndophytesWithaniaWithanolidesAntioxidantsInhibitory Concentration 50Molecular StructureAcetylcholinesteraseAntioxidantsCholinesterase InhibitorsWithanolides2,3-dihydrowithaferin AAcetylcholinesterase inhibitory activityAlzheimer's diseaseEndophytic fungiWithania somniferaWithanolide Z

Identifiers

PMID42458155
PMCPMC13373137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.