Evidence map›Paper›PMID 42458117›Full record

ArticleCellular and molecular life sciences : CMLS2026

FADS1-mediated Efferocytosis in Tumor-Associated Macrophages Shapes an Immunosuppressive Microenvironment in Gastric Cancer.

Yingjing Zhang, Rongyuan Wei, Pengfei Su, Yonghu Xu, Tian Yu, Bowen Hou, Jianchun Yu, Fenglin Liu, Yakai Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yingjing Zhang *Department of Gastric Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Rd., Xuhui District, Shanghai, 200032, China.
Rongyuan Wei *Department of Gastric Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Rd., Xuhui District, Shanghai, 200032, China.
Pengfei Su *Department of General Surgery, Cancer Center, Division of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Yonghu Xu *Department of Gastric Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Rd., Xuhui District, Shanghai, 200032, China.
Tian YuDepartment of Gastrointestinal Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
Bowen HouDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Jianchun YuDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China. yu-jch@163.com.
Fenglin LiuDepartment of Gastric Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Rd., Xuhui District, Shanghai, 200032, China. fenglinliu@hotmail.com.
Yakai HuangDepartment of Gastric Surgery, Fudan University Shanghai Cancer Center, No. 270 Dongan Rd., Xuhui District, Shanghai, 200032, China. huangyakai7067@163.com.ORCID http://orcid.org/0009-0008-3948-4715

Funding

National High Level Hospital Clinical Research Funding No. 2022-PUMCH-B-005Postdoctoral Research Funding Project of Zhejiang Province No. ZJ2024022
6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) play a central role in tumor progression and therapeutic resistance. Alterations in unsaturated fatty acids (UFAs) metabolism are known to contribute to the immunosuppressive properties of TAMs. However, the complex regulatory relationship between UFAs metabolism and TAMs during gastric cancer (GC) progression remains largely unclear. Through a comprehensive analysis of single-cell RNA sequencing and transcriptomic data, we found that the UFAs biosynthesis-related enzyme FADS1 holds prognostic significance in GC within TAMs. Clinically, a high infiltration of FADS1

Indexed as

Fatty Acid DesaturasesStomach NeoplasmsTumor-Associated MacrophagesTumor MicroenvironmentAnimalsCD8-Positive T-LymphocytesCell Line, TumorcGAS-STING Signaling PathwayDelta-5 Fatty Acid DesaturaseEfferocytosisHumansMiceMice, Inbred C57BLPPAR gammaSignal TransductionDelta-5 Fatty Acid DesaturaseFADS1 protein, humanFatty Acid DesaturasesPPAR gammaEfferocytosisFADS1Gastric cancerSTINGTumor-associated macrophages

Identifiers

PMID42458117
PMCPMC13654921

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.