Evidence map›Paper›PMID 42458116›Full record

ArticleAnnals of hematology2026

Clinical utility of copeptin in histiocytosis-associated arginine vasopressin deficiency: a report of three cases.

Luca Malatesta, Giuliana Marongiu, Francesco Pegoraro, Stefano Stagi, Marzia Mortilla, Marco Allinovi, Anna M Buccoliero, Elena Sieni, Augusto Vaglio

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luca Malatesta *Department of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, Florence, Italy.
Giuliana Marongiu *Department of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, Florence, Italy.
Francesco PegoraroHaematology and Oncology Department, Meyer Children's Hospital IRCCS, Firenze, Italy.
Stefano StagiDepartment of Health Sciences, University of Florence, Florence, Italy.
Marzia MortillaNeuroradiology, Meyer Children's Hospital IRCCS, Florence, Italy.
Marco AllinoviNephrology, Dialysis and Transplantation Unit, Careggi University Hospital, Florence, Italy.
Anna M BuccolieroPathology Unit, Meyer Children's Hospital IRCCS, Florence, Italy.
Elena SieniPediatric Hematology- Oncology Department, Meyer Children's Hospital IRCCS, Florence, Italy.
Augusto VaglioDepartment of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Viale Pieraccini 6, Florence, Italy. augusto.vaglio@unifi.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arginine vasopressin deficiency (AVP-D) is a frequent complication of histiocytosis and may precede the systemic manifestations of the disease of several years. Currently, no reliable biomarkers allow the diagnosis of AVP-D in the setting of histiocytosis. Traditional diagnostic methods, such as the water deprivation test, are often impractical. Copeptin, a new surrogate marker for arginine vasopressin, has been used for the diagnosis of AVP-D in other conditions, such as trauma and malignancies. We herein report three clinical cases of systemic histiocytosis (one Erdheim-Chester disease, one Rosai-Dorfman-Destombes disease, and one Langerhans cell histiocytosis) where plasma copeptin was utilized to identify AVP-D. The three cases differed not only because of the underlying diagnosis, but also in terms of clinical characteristics and rapidity of onset of AVP-D. We propose an early integration of copeptin into the diagnostic workup of systemic histiocytosis.

Indexed as

Arginine VasopressinGlycopeptidesHistiocytosisHistiocytosis, Langerhans-CellHistiocytosis, SinusBiomarkersHumansArginine VasopressinBiomarkerscopeptinsGlycopeptidesarginine vasopressin deficiency.copeptinErdheim-Chester diseaseLangerhans-cell histiocytosisRosai-Dorfman disease

Identifiers

PMID42458116
PMCPMC13654884

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.