ArticleNature structural & molecular biology2026
ESCRT-III assembles around mis-segregated DNA to protect genome stability.
Article in Nature structural & molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A protective ESCRT sleeve for ultrafine DNA bridges.Nature structural & molecular biology · 2026Article
- Phosphatidylinositol diphosphate binding by ESCRT-III filaments.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Funding
Abstract
Chromosome mis-segregation events that remain unresolved during cytokinesis threaten genome stability. Persistent ultrafine DNA bridges engage the Aurora B-dependent abscission checkpoint (termed NoCut), which delays abscission by phosphorylating components of the ESCRT complex. Here we show that NoCut surveillance repurposes human ESCRT-III, the membrane-remodeling complex that seals the reforming nuclear envelope in anaphase. In response to persistent ultrafine DNA bridges, ESCRT-III transfers from the reforming nuclear envelope to the mis-segregated DNA bridge and ESCRT-III complexes protect the DNA from damage, as evidenced by increased DNA damage upon CHMP1B depletion. Complementary in vitro assembly reactions show that the human ESCRT-III proteins CHMP1B and IST1 can copolymerize into double-stranded filaments that encase double-stranded DNA and nucleosomes and prevent nuclease digestion and cGAS recognition, demonstrating that ESCRT-III complexes can directly bind and protect DNA. Lastly, cells expressing a DNA-binding mutant of CHMP1B exhibit cytokinesis failure and binucleation when ultrafine DNA bridges persist, revealing a mechanism of safeguarding genome stability.
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Registered trials
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