Evidence map›Paper›PMID 42458103›Full record

ArticleLung2026

FeNO as a Treatable Trait in Chronic Cough: Insights from the PROCOUGH Study.

Mustafaa Wahab, Elena Kum, Nermin Diab, Danica Brister, Ana Oliveira, Wafa Hassan, Sue Beaudin, Catie Stevens, Jennifer Wattie, Lesley Wiltshire and 6 more

Abstract read
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In one paragraph

Article in Lung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mustafaa WahabDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Elena KumDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Nermin DiabDepartment of Medicine, The Research Institute of the McGill University Health Centre, McGill University, Montreal, QC, Canada.
Danica BristerDepartment of Medicine, University of Calgary, Calgary, AB, Canada.
Ana OliveiraRespiratory Research and Rehabilitation Laboratory (Lab3R), School of Health Sciences (ESSUA), University of Aveiro, Aveiro, Portugal.
Wafa HassanDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Sue BeaudinDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Catie StevensDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Jennifer WattieDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Lesley WiltshireDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Karen HowieDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Kieran KillianDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Roma SehmiDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Gail M GauvreauDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Paul M O'ByrneDepartment of Medicine, McMaster University, Hamilton, ON, Canada.
Imran SatiaDepartment of Medicine, McMaster University, Hamilton, ON, Canada. satiai@mcmaster.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeType 2 (T2) inflammatory biomarkers are established therapeutic targets in asthma and non-asthmatic eosinophilic bronchitis (NAEB), but their relevance in chronic cough remains unclear. Therefore, the objective of our study was to evaluate the relationship between T2 biomarkers and cough outcomes, and to determine their ability to predict treatment response and cough control.

methodsThis post-hoc analysis of the prospective PROCOUGH cohort included 100 patients with chronic cough. Patients underwent comprehensive phenotyping and were classified as chronic cough secondary to asthma/NAEB (CC

resultsBaseline FeNO and sputum eosinophils were higher in CC

conclusionFeNO represents a modest predictor of treatment response and cough control in chronic cough but not RCC. These findings support its role as a treatable trait.

Indexed as

Adrenal Cortex HormonesAdrenergic beta-2 Receptor AgonistsAsthmaBronchitisChronic CoughCoughNitric OxideAdministration, InhalationAdultBiomarkersChronic DiseaseEosinophiliaEosinophilsFemaleFractional Exhaled Nitric Oxide TestingHumansAdrenal Cortex HormonesAdrenergic beta-2 Receptor AgonistsBiomarkersNitric OxideBiomarkersChronic coughFractional exhaled nitric oxideRefractory chronic coughTreatable traitsType 2 inflammation

Identifiers

PMID42458103

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.