Evidence map›Paper›PMID 42458100›Full record

ArticleNature methods2026

Simultaneous single-cell calcium imaging of neuronal population activity and brain-wide BOLD fMRI.

Rik L E M Ubaghs, Roman Boehringer, Markus Marks, Helke K Hesse, Mehmet Fatih Yanik, Valerio Zerbi, Benjamin F Grewe

Abstract read
In one paragraph

Article in Nature methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rik L E M UbaghsInstitute of Neuroinformatics, ETH Zurich and University of Zurich, Zurich, Switzerland. ubaghsr@ethz.ch.ORCID http://orcid.org/0009-0005-1638-9529
Roman BoehringerInstitute of Neuroinformatics, ETH Zurich and University of Zurich, Zurich, Switzerland.
Markus MarksDivision of Engineering and Applied Science, California Institute of Technology, Pasadena, USA.ORCID http://orcid.org/0000-0001-8016-1637
Helke K HesseHesse - Optical Consulting, Gießen, Germany.
Mehmet Fatih YanikInstitute of Neuroinformatics, ETH Zurich and University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-8963-2893
Valerio ZerbiDepartment of Psychiatry, Faculty of Medicine, University of Geneva, Genève, Switzerland.
Benjamin F GreweInstitute of Neuroinformatics, ETH Zurich and University of Zurich, Zurich, Switzerland. bgrewe@ethz.ch.ORCID http://orcid.org/0000-0001-8560-2120

Funding

Multimodal, integrated analysis of neural activity and naturalistic social behavior in freely moving miceR01MH123612 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ANDERSON, DAVID J, PERONA, PIETRO · 2020 to 2024
$2.1M
NIMH NIH HHS R01 MH123612
6 · The paper itself

Abstract

Functional magnetic resonance imaging (fMRI) based on the blood-oxygen-level-dependent (BOLD) signal is widely used to study brain activity non-invasively. However, the relationship between the local neural population activity and vascular activity, as measured by BOLD fMRI, remains incompletely understood. Here we show that simultaneous measurement of cellular calcium (Ca

Indexed as

BrainCalciumMagnetic Resonance ImagingNeuronsSingle-Cell AnalysisAnimalsBrain MappingMiceOxygenCalciumOxygen

Identifiers

PMID42458100
PMCPMC13441971

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.