Evidence map›Paper›PMID 42458052›Full record

ArticleNature biotechnology2026

Multiscale in vivo imaging of tumor evolution using a germline conditional triple-reporter mouse.

Ximena L Raffo-Iraolagoitia, Abdullah Alyamani, Stephanie May, David Stevenson, Agata Mackintosh, Lynn McGarry, Jayanthi Anand, Dmitry Soloviev, Gavin Brown, Colin Nixon and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Ximena L Raffo-IraolagoitiaCancer Research UK Scotland Institute, Glasgow, UK.
Abdullah AlyamaniCancer Research UK Scotland Institute, Glasgow, UK.
Stephanie MayCancer Research UK Scotland Institute, Glasgow, UK.ORCID http://orcid.org/0000-0003-0095-7403
David StevensonCancer Research UK Scotland Institute, Glasgow, UK.
Agata MackintoshCancer Research UK Scotland Institute, Glasgow, UK.
Lynn McGarryCancer Research UK Scotland Institute, Glasgow, UK.ORCID http://orcid.org/0000-0002-7055-2615
Jayanthi AnandCancer Research UK Scotland Institute, Glasgow, UK.
Dmitry SolovievSchool of Cancer Sciences, University of Glasgow, Glasgow, UK.
Gavin BrownCancer Research UK Scotland Institute, Glasgow, UK.
Colin NixonCancer Research UK Scotland Institute, Glasgow, UK.ORCID http://orcid.org/0000-0002-8085-2160
Chrysa KapeniCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
Maike De La RocheCancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.ORCID http://orcid.org/0000-0002-0558-4119
Karen BlythCancer Research UK Scotland Institute, Glasgow, UK.ORCID http://orcid.org/0000-0002-9304-439X
Thomas Graham BirdCancer Research UK Scotland Institute, Glasgow, UK.ORCID http://orcid.org/0000-0002-6120-1581
Douglas StrathdeeCancer Research UK Scotland Institute, Glasgow, UK.ORCID http://orcid.org/0000-0003-2959-4327
Scott K LyonsCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0003-0139-6054
Gilbert FruhwirthImaging Therapies and Cancer Group, Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Sciences, King's College London, Guy's Cancer Centre, London, UK.ORCID http://orcid.org/0000-0002-1438-2674
Leo M CarlinCancer Research UK Scotland Institute, Glasgow, UK.ORCID http://orcid.org/0000-0001-7172-5234
David Y LewisCancer Research UK Scotland Institute, Glasgow, UK. david.lewis@glasgow.ac.uk.ORCID http://orcid.org/0000-0001-9329-1326

Funding

Cancer Research UK (CRUK) A13827Cancer Research UK (CRUK) A21153Cancer Research UK (CRUK) A23983Cancer Research UK (CRUK) A25006Cancer Research UK (CRUK) A29799Cold Spring Harbor Laboratory (CSHL) 5P30CA045508Wellcome Trust (Wellcome) WT107492Z
6 · The paper itself

Abstract

Imaging reporter genes are essential tools in cancer research for monitoring tumor evolution, cell dissemination, gene activation and treatment response. However, germline reporter models typically rely on single imaging modalities operating over limited spatial scales. To address these limitations, we developed an inducible triple-reporter mouse model (Rosa26

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.