Evidence map›Paper›PMID 42458051›Full record

Observational studyDigestive diseases and sciences2026

A Single-Center Retrospective Cohort Review of Pancreatic Cysts and Malignancy in Cystic Fibrosis Lung Transplant Recipients.

Yasseen El Abdellaoui, Daniel Dong, Julia Zweifach, Grace McDevitt, Logan O Gauthier, Avinash Kambadakone, Sophia Zhao, Christopher Vélez, Yasmin G Hernandez-Barco, Isabel Neuringer

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yasseen El AbdellaouiPediatric Cystic Fibrosis Center, Massachusetts General Hospital, Boston, MA, USA.
Daniel DongAdult Cystic Fibrosis Center, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0009-0006-2826-9126
Julia ZweifachPediatric Cystic Fibrosis Center, Massachusetts General Hospital, Boston, MA, USA.
Grace McDevittPediatric Cystic Fibrosis Center, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0009-0003-3033-6912
Logan O GauthierPediatric Cystic Fibrosis Center, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0009-0003-9847-6735
Avinash KambadakoneDepartment of Radiology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6714-9190
Sophia ZhaoPulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, USA.
Christopher VélezCenter for Neurointestinal Health, Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0498-6850
Yasmin G Hernandez-BarcoPancreas and Biliary Program, Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1266-3218
Isabel NeuringerAdult Cystic Fibrosis Center, Massachusetts General Hospital, Boston, MA, USA. ineuringer@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIndividuals with cystic fibrosis (CF) develop pancreatic cysts and cancer more frequently than the general population, particularly among lung transplant recipients due to long-term immunosuppression. CF lung transplant guidelines address many gastrointestinal malignancies including colorectal cancer, but do not provide recommendations for routine surveillance of the pancreas.

aimsWe aim to highlight the increased risk that CF lung transplant patients face for developing pancreatic cysts and malignancy. This study may inform future multicenter studies and guideline revisions to include monitoring of the pancreas in this population.

methodsAn observational, retrospective chart review of CF lung transplant recipients (N = 54) was conducted monitoring pancreatic cyst incidence and severity. Statistics and figures were generated in RStudio.

resultsTwenty-two patients (40.7%) had pancreatic cystic lesions. Nearly, all patients underwent post-transplant, abdominal CT (100%), and ultrasound (98.1%), while 30 patients (55.6%) received an MRI/MRCP. Of those with cysts, 7 (31.8%) had cysts detected pre-transplant, while 15 (68.2%) had cysts detected post-transplant. Seven patients (31.8%) were diagnosed with suspected IPMNs. Seven patients (31.8%) had cysts measuring ≥ 30 mm, 4 (18.2%) exhibited main pancreatic duct dilation > 5 mm, and 8 patients (36.4%) showed a cystic growth rate ≥ 3.0 mm per year. Seven individuals (13.0%) had their cysts sampled for malignancy; two (3.7%) were diagnosed with pancreatic cancer and an additional patient experienced rapid multifocal cyst progression and underwent total pancreatectomy.

conclusionFindings indicate a higher-than-expected pancreatic cyst and cancer prevalence, supporting the need for formal screening guidelines for CF lung transplant recipients.

Indexed as

Cystic FibrosisLung TransplantationPancreatic CystPancreatic NeoplasmsAdolescentAdultFemaleHumansIncidenceMaleMiddle AgedRetrospective StudiesRisk FactorsYoung AdultCystic fibrosisLung transplantPancreatic cancerPancreatic cystosisPancreatic cysts

Identifiers

PMID42458051

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.