Evidence map›Paper›PMID 42457960›Full record

ArticleNature2026

Metabolite glues as a means of purine sensing and chemotherapeutic response.

Samuel R Witus, Megan M Kober, Heegwang Roh, Zhi Yang, Fouad Choueiry, Avani S Ghate, Denis V Titov, Michael Rapé

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Localized heme sensing through a ternary molecular glue.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samuel R WitusDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-1907-8484
Megan M KoberDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-3909-9573
Heegwang RohDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-1549-2437
Zhi YangDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-8680-3784
Fouad ChoueiryDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0009-0002-3350-8217
Avani S GhateDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0009-0003-5781-3176
Denis V TitovDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-5677-0651
Michael RapéDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. mrape@berkeley.edu.ORCID http://orcid.org/0000-0003-4849-6343

Funding

Toward a quantitative understanding of metabolic homeostasisR35GM152114 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Denis Vasilievich Titov · 2024 to 2026
$1.4M
NIGMS NIH HHS R35 GM152114
6 · The paper itself

Abstract

Molecular glues stabilize weak interactions to impart new functionalities to complexes

Indexed as

PurinesPyrophosphatasesAmidophosphoribosyltransferaseEnzyme InhibitorsFeedback, PhysiologicalHumansModels, MolecularAmidophosphoribosyltransferaseEnzyme InhibitorspurinePurinesPyrophosphatases

Identifiers

PMID42457960
PMCPMC13421311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.