ArticleCell death and differentiation2026
PAD4-generated citrullinated histones are triggers for autoinflammation in cryopyrin-associated periodic syndrome.
Bregje Christiaenssen, Silke Mortelmans, Siham Baghli, Fleur Boone, Wei Xie, Arinna Bertoni, My Ha, Benson Ogunjimi, Vito Sabato, Marco Gattorno and 4 more
Abstract read
In one paragraphArticle in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
14 authors.
Siham BaghliCell Death Signaling Laboratory, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium.
Wei XieVIB Center for Inflammation Research, VIB, Ghent, Belgium.
Arinna BertoniUOC Reumatologia e Malattie Autoinfiammatorie, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
My HaAntwerp Center for Translational Immunology and Virology (ACTIV), Center for Health Economics Research and Modeling Infectious Diseases (CHERMID), Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.
Benson OgunjimiAntwerp Center for Translational Immunology and Virology (ACTIV), Center for Health Economics Research and Modeling Infectious Diseases (CHERMID), Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.
Vito SabatoDepartment of Immunology, Allergology, and Rheumatology, Antwerp University Hospital, Edegem, Belgium.
Marco GattornoUOC Reumatologia e Malattie Autoinfiammatorie, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Andy WullaertCell Death Signaling Laboratory, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium. andy.wullaert@uantwerpen.be.ORCID http://orcid.org/0000-0001-5012-654X Funding
Bijzonder Onderzoeksfonds (Special Research Fund) 01IB3920Bijzonder Onderzoeksfonds (Special Research Fund) 01M00709Bijzonder Onderzoeksfonds (Special Research Fund) BOF23/GOA/001Bijzonder Onderzoeksfonds (Special Research Fund) IMPULSFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 11P3Q24NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 3G033120Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 3G0A9322Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 3G0AA824Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) 3G0I5722Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) EOS-G0H2522N-40007505Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G071224NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G0A3422NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) G0A7O24NFonds Wetenschappelijk Onderzoek (Research Foundation Flanders) S006425NStichting Tegen Kanker (Belgian Foundation Against Cancer) 365A08921Stichting Tegen Kanker (Belgian Foundation Against Cancer) 365G09122Stichting Tegen Kanker (Belgian Foundation Against Cancer) 365L04523
6 · The paper itselfAbstract
Cryopyrin-associated periodic syndromes (CAPS) are autoinflammatory disorders caused by gain-of-function NLRP3 variants. Although NLRP3 inflammasomes mediate IL-1β secretion through Gasdermin D (GSDMD), we show that GSDMD deletion did not prevent autoinflammation in mice ubiquitously expressing the Nlrp3
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