Evidence map›Paper›PMID 42457904›Full record

ReviewCommunications biology2026

Multiscale brain development across the human lifespan.

Sahar Ahmad, Pew-Thian Yap

Abstract readReview
In one paragraph

Review in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sahar AhmadDepartment of Radiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. sahar967@email.unc.edu.ORCID 0000-0001-7243-9977
Pew-Thian YapDepartment of Radiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ptyap@med.unc.edu.ORCID 0000-0003-1489-2102

Funding

Longitudinal Mapping of Human Brain Development in the First Years of LifeR01EB008374 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2009 to 2024
$5.1M
Computational Diffusion MRI for Studying Early Human Brain DevelopmentR01MH125479 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2021 to 2025
$2.1M
Optimized High-Resolution Fast Magnetic Resonance Fingerprinting with Cloud-Based ReconstructionR01NS134849 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Yong Chen, Pew-Thian Yap · 2024 to 2026
$1.9M
Multifaceted Characterization of Early Human Brain DevelopmentR01MH133836 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2024 to 2025
$1.2M
AI-Powered MRI Quality Control and Artifact Correction for Multi-Site StudiesR01EB035160 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Pew-Thian Yap · 2024 to 2026
$1.2M
NIBIB NIH HHS R01 EB008374NIBIB NIH HHS R01 EB035160NIMH NIH HHS R01 MH125479NIMH NIH HHS R01 MH133836NINDS NIH HHS R01 NS134849U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) R01EB008374U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) R01EB035160U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH125479U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH133836U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS134849
6 · The paper itself

Abstract

Deciphering how the human brain matures and reorganizes across the lifespan remains a central challenge in developmental neuroscience. Understanding the complex developmental processes is essential for elucidating the biological bases of cognition and behavior, as well as the mechanisms underlying aging and neurodegenerative diseases. Neuroimaging has enabled the mapping of nonlinear, age-related changes in brain morphology, microstructure, and connectivity from gestation to senescence. However, we lack a unified understanding of interplay across multimodal neuroimaging measures, structure-function coupling, and the cellular and molecular drivers of network reorganization. In this review, we synthesize current evidence to provide a multiscale MRI-derived account of structural and functional brain development across the human lifespan, highlight key conceptual and methodological gaps, and outline priorities for future research.

Indexed as

AgingBrainLongevityHumansMagnetic Resonance ImagingNeurodevelopmentNeuroimaging

Identifiers

PMID42457904
PMCPMC13373200

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.