ArticleNature communications2026
Direct coupling of nod factor signaling to vesicular trafficking initiates legume nodulation.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Legume-rhizobium symbiosis requires coordinated receptor signaling and membrane trafficking to initiate infection thread formation in root hairs. Here, we identify the soybean Qa-SNARE GmSYNTAXIN111a (GmSYP111a), a close paralog of the cytokinesis-associated protein KNOLLE, as a critical regulator of symbiotic infection. Kinase-client assays and in vivo immunoprecipitation-mass spectrometry showed that GmSYP111a is phosphorylated by the receptor kinase GmSymRKβ at Ser-8 and Ser-128. BiFC, co-immunoprecipitation, and kinase assays validated the interaction and phosphorylation. Nod factor perception promoted clathrin-mediated endocytosis of the GmSymRKβ-GmSYP111a complex and its relocalization to intracellular vesicles. Structural modeling and interaction assays suggest that dual phosphorylation exposes an endocytic motif that recruits the TPLATE adaptor; accordingly, non-phosphorylatable mutations impaired internalization, whereas phosphomimetic substitutions induced endocytosis without rhizobial stimulation. GmSYP111a also interacted with VAMP72, linking endocytic recruitment to vesicle fusion. Genetic analyses in soybean and Lotus japonicus established a conserved requirement for GmSYP111a in nodule initiation. These findings define a phosphorylation-dependent SNARE switch that couples Nod factor signaling to membrane trafficking during legume nodulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.