ArticleNature communications2026
Investigating relationships between loneliness, social isolation and health.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Loneliness and social isolation are important public health concerns due to their associations with a range of health outcomes. However, it is difficult to ascertain whether any effects are biased by confounding and reverse causation. We use a triangulation approach combining observational, sibling control, and Mendelian Randomisation analyses (a genetically informed analysis), to draw robust conclusions about these relationships. Using a combination of UK Biobank data (N = 8,004 to 414,432) and genome-wide association studies (N = 17,526 to 2,083,151), we examine relationships between loneliness and social isolation and outcomes related to physical health, mental health and wellbeing and general health (e.g., multimorbidity capturing both mental and physical health). We find evidence for effects of loneliness and social isolation on poorer mental health and wellbeing and of loneliness on poorer general health. We do not find evidence of effects on specific physical health outcomes; however, these effects cannot definitively be ruled out.
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Registered trials
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