In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Lipin LooCharles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW, Australia.ORCID http://orcid.org/0000-0002-4112-1816 Kazuma FujikakeCharles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW, Australia.ORCID http://orcid.org/0000-0001-9271-8164 Grace CunliffeCharles Perkins Centre, School of Pharmacy, University of Sydney, Camperdown, NSW, Australia.
Sasha SaadCharles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW, Australia.
Teleri ClarkCharles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW, Australia.
Zina HamoudiCharles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW, Australia.
John ManionCharles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW, Australia.ORCID http://orcid.org/0000-0002-2716-3833 Leslie CaronCharles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW, Australia.ORCID http://orcid.org/0000-0003-4118-2974 Olivia C DavisDepartment of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Richardson, TX, USA.
G Gregory NeelyCharles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW, Australia. greg.neely@sydney.edu.au.ORCID http://orcid.org/0000-0002-1957-9732 Funding
Mechanistic underpinnings of chronic low back painU19NS130608 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI Michele Curatolo, Patrick M Dougherty · 2022 to 2026
$13.6MDepartment of Health | National Health and Medical Research Council (NHMRC) 1111940Department of Health | National Health and Medical Research Council (NHMRC) 1158165Department of Health | National Health and Medical Research Council (NHMRC) 2011547Department of Health | National Health and Medical Research Council (NHMRC) 2019164Department of Health | National Health and Medical Research Council (NHMRC) 2020590Department of Health | National Health and Medical Research Council (NHMRC) 2047901NINDS NIH HHS U19 NS130608
6 · The paper itselfAbstract
Chronic pain caused by peripheral nerve injury involves altered spinal pain transduction, where enhanced excitatory and/or reduced inhibitory pathways can drive pain. The cellular transcriptional changes that sustain entrenched neuropathic pain remain poorly understood. Here we use single-nucleus and spatial transcriptomic approaches in male mice to investigate spinal cellular and molecular programs associated with entrenched and treated neuropathic pain. We show that nerve injury leads to broad upregulation of synaptic and excitatory pathways in dorsal neuronal and glial populations. We confirm that these core populations are conserved in the human spinal cord, and show that an effective pain therapy dampens neuropathic transcriptional programs. These data identify spinal cell populations and pathways associated with neuropathic pain states and therapeutic reversal.
Indexed as
NeuralgiaPeripheral Nerve InjuriesSpinal CordAnimalsHumansMaleMiceMice, Inbred C57BLNeurogliaNeuronsTranscriptome
Identifiers
PMID42457652
PMCPMC13490565
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390