Evidence map›Paper›PMID 42457473›Full record

ArticleTrends in biotechnology2026

Point-of-care GlycoStrips detect serum and salivary antibodies to blood group antigens and pathogens.

Tianwei Jia, Akul Y Mehta, Kelsey M Charon, Maxence Noel, Praveen Singh, Stephan von Gunten, John D Roback, Jamie Heimburg-Molinaro, Sean R Stowell, Richard D Cummings

Abstract read
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Article in Trends in biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tianwei JiaDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle, Boston, MA 02115, USA; Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Akul Y MehtaDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle, Boston, MA 02115, USA.
Kelsey M CharonDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle, Boston, MA 02115, USA.
Maxence NoelDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle, Boston, MA 02115, USA.
Praveen SinghDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle, Boston, MA 02115, USA.
Stephan von GuntenInstitute of Pharmacology, University of Bern, Inselspital, INO-F, Bern 3010, Switzerland.
John D RobackCenter for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Jamie Heimburg-MolinaroDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle, Boston, MA 02115, USA.
Sean R StowellJoint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, 630E New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
Richard D CummingsDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle, Boston, MA 02115, USA. Electronic address: rcummin1@bidmc.harvard.edu.

Funding

Project 2 - Convergence of innate immunity and microbial communities in the regulation of anti-blood group antibody developmentP01HL171803 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Sean R Stowell · 2024 to 2026
$10.0M
Protein-Glycan Interaction Resource at the National Center for Functional Glycomics (NCFG)R24GM137763 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RICHARD D CUMMINGS · 2020 to 2026
$5.8M
NHLBI NIH HHS P01 HL171803NIGMS NIH HHS R24 GM137763
6 · The paper itself

Abstract

Antibodies to carbohydrate antigens present in blood group substances and pathogens are important to human health, transplantation, and transfusion medicine. Identifying such antibodies typically requires complex technologies and instrumentation. To address this limitation, we prepared neoglycoproteins densely representing ABO(H) blood group glycan epitopes and printed them in an alphanumeric format on nitrocellulose paper strips, termed 'GlycoStrip', representing a point-of-care device. Binding of anti-ABO(H) antibodies present in serum or saliva is easily visualized after the application of a colorimetric reagent. Results demonstrate distinct anti-glycan IgA and IgG repertoires in each individual tested, providing inferences regarding the ABO status of the donor. Antibody repertoire profiles were corroborated using Luminex and glycan microarray technologies. We prepared GlycoStrips containing pathogen-associated materials and intact bacterial cells to which serum IgG antibodies detectably bound. Results demonstrate the versatility and ease of GlycoStrip in detecting antibodies to a wide variety of antigens, representing a transformative tool for diagnostics and personalized medicine.

Indexed as

antibodiesanti-glycan antibodiesblood group antigensglycan microarraypoint-of-care device

Identifiers

PMID42457473
PMCPMC13378435

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.