Evidence map›Paper›PMID 42457404›Full record

ArticleZoological research2026

Prefrontal cortex to dorsal medial striatum neural circuitry mediates social interaction.

Meng-Wei Zhang, Shao-Hui Chen, Hai-Li Zhu, Li-Jun Zhang, Shuang Wang, Qing Yao, Shu-Wei Hua, Ning-Hua Wu, Wei Meng, Ling Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zoological research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Meng-Wei ZhangHubei Key Laboratory of Diabetes and Angiopathy, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, 437100, China.
Shao-Hui ChenHubei Key Laboratory of Diabetes and Angiopathy, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, 437100, China.
Hai-Li ZhuHubei Key Laboratory of Diabetes and Angiopathy, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, 437100, China.
Li-Jun ZhangHubei Key Laboratory of Diabetes and Angiopathy, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, 437100, China.
Shuang WangHubei Key Laboratory of Diabetes and Angiopathy, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, 437100, China.
Qing YaoHubei Key Laboratory of Diabetes and Angiopathy, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, 437100, China.
Shu-Wei HuaSchool of Stomatology and Ophthalmology, Hubei University of Science and Technology, Xianning 437100, China.
Ning-Hua WuHubei Key Laboratory of Diabetes and Angiopathy, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, 437100, China.
Wei MengHubei Key Laboratory of Diabetes and Angiopathy, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, 437100, China.
Ling LiuHubei Key Laboratory of Diabetes and Angiopathy, School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, 437100, China. E-mail: liuling0306@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prefrontal cortex and striatum have been implicated in social interaction while the underpinning neuronal and circuit mechanisms remain poorly understood. Here, we report that frontostriatal neurons are strongly activated when naive male C57BL/6J mice interact with a conspecific. Furthermore, cell-type-specific inhibition or activation of these neurons substantially impairs social interaction. Moreover, optogenetic inhibition of the prefrontal cortex (PFC)-dorsomedial striatum (DMS) pathway significantly disrupts social interaction. These findings reveal a key function of frontostriatal neurons in social interaction and suggest that selectively targeting the PFC-DMS circuit may help alleviate social dysfunction in related disorders.

Indexed as

Corpus StriatumPrefrontal CortexSocial BehaviorAnimalsMaleMiceMice, Inbred C57BLNeural PathwaysNeuronsDorsal medial striatumFrontostriatal neuronMultichannel recordingPrefrontal cortexSocial interaction

Identifiers

PMID42457404
PMCPMC13662588

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.