Evidence map›Paper›PMID 42457339›Full record

ArticleJournal for immunotherapy of cancer2026

Chang-Jung Lee, Alex T Larsson, Tyler A Jubenville, Wendy A Hudson, Zach J Seeman, Carli Stewart, Alexander K Tsai, Adam Burrack, Brooke L Kimball, Elizabeth L Siegler and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Chang-Jung LeeUniversity of Minnesota Twin Cities Department of Genetics Cell Biology and Development, Minneapolis, Minnesota, USA lee02894@umn.edu.ORCID http://orcid.org/0009-0008-9841-1874
Alex T LarssonUniversity of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, USA.
Tyler A JubenvilleUniversity of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, USA.
Wendy A HudsonUniversity of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, USA.
Zach J SeemanUniversity of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, USA.
Carli StewartT Cell Engineering Laboratory Program, Mayo Clinic Rochester, Rochester, Minnesota, USA.ORCID http://orcid.org/0000-0002-2288-2230
Alexander K TsaiUniversity of Minnesota Twin Cities Center for Immunology, Minneapolis, Minnesota, USA.ORCID http://orcid.org/0000-0002-4014-1946
Adam BurrackUniversity of Minnesota Twin Cities Center for Immunology, Minneapolis, Minnesota, USA.
Brooke L KimballT Cell Engineering Laboratory Program, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Elizabeth L SieglerT Cell Engineering Laboratory Program, Mayo Clinic Rochester, Rochester, Minnesota, USA.
Vianca V VianzonDepartment of Immunology, Mayo Clinic Rochester, Rochester, Minnesota, USA.ORCID http://orcid.org/0000-0003-3072-5646
Erin E NolanUniversity of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, USA.
Yu-Ling YangUniversity of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, USA.
Christopher M StehnUniversity of Minnesota Twin Cities Department of Genetics Cell Biology and Development, Minneapolis, Minnesota, USA.
Daryl M GohlUniversity of Minnesota Twin Cities Department of Genetics Cell Biology and Development, Minneapolis, Minnesota, USA.
Margaret DonovanUniversity of Minnesota Twin Cities Genomics Center, Minneapolis, Minnesota, USA.
Nuri A TemizUniversity of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, USA.
Flavia E PopescuUniversity of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, USA.
Søren WarmingGenentech Inc, South San Francisco, California, USA.
Somasekar SeshagiriGenentech Inc, South San Francisco, California, USA.
Yun YouMouse Genetics Laboratory, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
Jesse D RiordanHolden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa, USA.
Adam DupuyHolden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa, USA.
Branden MoriarityUniversity of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, USA.
Laura RogersDepartment of Immunology, Mayo Clinic Rochester, Rochester, Minnesota, USA.ORCID http://orcid.org/0000-0003-0861-3269
Ingunn StromnesUniversity of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, USA.ORCID http://orcid.org/0000-0001-8120-4547
Saad KenderianDepartment of Immunology, Mayo Clinic Rochester, Rochester, Minnesota, USA.
David LargaespadaUniversity of Minnesota Twin Cities Department of Genetics Cell Biology and Development, Minneapolis, Minnesota, USA.ORCID http://orcid.org/0000-0002-3183-0491

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Timothy C. Hallstrom · 1998 to 2026
$100.4M
Towards Safer and More Effective CART Cell Therapy Through the Modulation of Myeloid CytokinesR37CA266344 · NCI · MAYO CLINIC ROCHESTER · PI Saad J. Kenderian · 2022 to 2026
$3.5M
NCI NIH HHS P30 CA077598NCI NIH HHS R37 CA266344
6 · The paper itself

Abstract

backgroundGenes that enhance T-cell function represent promising targets for improving engineered T-cell therapies for cancer. While extensive CRISPR knockout screens have identified key genes enhancing T-cell persistence, employing

methodsWe developed transgenic mice carrying

resultsUnder chronic stimulation,

conclusionsControllable

Indexed as

Antigens, NeoplasmBasic-Leucine Zipper Transcription FactorsCD8-Positive T-LymphocytesImmunotherapy, AdoptiveReceptors, Chimeric AntigenAnimalsHumansMiceMice, TransgenicMutagenesisMutagenesis, InsertionalT-Cell ExhaustionAntigens, NeoplasmBach2 protein, mouseBasic-Leucine Zipper Transcription FactorsReceptors, Chimeric AntigenAdoptive cell therapy - ACTChimeric antigen receptor - CARGene expression profiling - GEPNext generation sequencing - NGST cell

Identifiers

PMID42457339
PMCPMC13374443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.