Evidence map›Paper›PMID 42457338›Full record

SynthesisBMJ mental health2026

Systematically developed, comprehensive atlas of unique evidence-based psychological interventions for severe mental disorders.

Giuliano Tomei, Chrysanthi Blithikioti, Camilla Cadorin, Lorena Pizzocri, Fabrizio Visconti, Marcella Lucente, Irene Gómez-Gómez, Ioana Alina Cristea

Abstract readSystematic Review
In one paragraph

Synthesis in BMJ mental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Giuliano TomeiDepartment of General Psychology, Università degli Studi di Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-1516-1830
Chrysanthi BlithikiotiDepartment of General Psychology, Università degli Studi di Padova, Padova, Italy.ORCID http://orcid.org/0000-0003-4569-9639
Camilla CadorinDepartment of General Psychology, Università degli Studi di Padova, Padova, Italy.ORCID http://orcid.org/0000-0002-7642-2096
Lorena PizzocriDepartment of General Psychology, Università degli Studi di Padova, Padova, Italy.ORCID http://orcid.org/0009-0003-5293-6038
Fabrizio ViscontiDepartment of General Psychology, Università degli Studi di Padova, Padova, Italy.ORCID http://orcid.org/0009-0007-2774-8616
Marcella LucenteDepartment of General Psychology, Università degli Studi di Padova, Padova, Italy.ORCID http://orcid.org/0000-0001-8396-8639
Irene Gómez-GómezUniversidad de Sevilla, Seville, Spain.ORCID http://orcid.org/0000-0001-8014-6955
Ioana Alina CristeaDepartment of General Psychology, Università degli Studi di Padova, Padova, Italy ioanaalina.cristea@unipd.it.ORCID http://orcid.org/0000-0002-9854-7076

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe existent classifications of the distinct evidence-based psychological interventions (EBPs) are broad, not systematically developed or restricted to one mental disorder.

objectiveTo identify the unique EBPs and their variations evaluated for six severe mental disorders (schizophrenia and psychosis, bipolar disorders, bulimia nervosa, anorexia nervosa, one type of substance use and borderline personality). STUDY SELECTION AND ANALYSIS: We established a large cohort of EBPs by selecting all randomised controlled trials (RCTs) from six recent and large network meta-analyses for severe mental disorders in adults. Pairs of researchers independently selected all psychological intervention arms and assigned them to macro-families based on labels and theoretical background. Subsequently, within each macro-family, groups of identical arms, that is, referencing the same manual or protocol, were consolidated as distinct psychological interventions. Adaptations related to content, structure, delivery or culture were also described.

findingsFrom 260 RCTs, 422 psychological intervention arms were grouped in 45 macro-families and reduced to 266 distinct interventions (63% of total arms) across disorders. Intervention variability, that is, the proportion of unique psychological interventions out of the total number of arms, was lowest for the substance use disorder selected-stimulant use disorder (47/104, 45%) and bulimia nervosa (25/45, 55.5%). Variability was high for bipolar disorders (48/59, 81%), anorexia nervosa (20/29, 69%), schizophrenia/psychosis (86/123, 70%) and borderline personality disorder (40/62, 64.5%). 79 of the 266 distinct interventions (29%) contained adaptations (12% multiple adaptations) and 75/266 (28%) had openly available manuals or protocols. CONCLUSIONS AND CLINICAL IMPLICATIONS: Mapping EBPs across macro-families and distinct interventions could inform evidence synthesis and identification of active ingredients, guide mechanisms of change exploration and support prioritising interventions for research and dissemination.

Indexed as

Mental DisordersPsychosocial InterventionPsychotherapyHumansRandomized Controlled Trials as TopicAnorexia NervosaBipolar and Related DisordersBorderline Personality DisorderPsychotherapyPsychotic Disorders

Identifiers

PMID42457338
PMCPMC13386039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.