ArticleLupus science & medicine2026
Integrated immune profiling identifies a coordinated T-cell activation and inflammatory signature in SLE.
Article in Lupus science & medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionPatients with SLE have an increased risk of infections and infection-related mortality, which may be associated with disturbances in immune cell populations. Despite extensive research, findings regarding T-cell and B-cell alterations in SLE remain inconsistent. Therefore, we analysed peripheral blood immune cell subpopulations and their molecular profiles in patients with SLE with renal involvement compared with healthy controls (HCs).
methodsThe phenotype and gene expression of lymphocytes from patients with SLE and lupus nephritis and healthy donors were assessed using flow cytometry and quantitative PCR. Exploratory multivariate and treatment-sensitivity analyses were performed to evaluate global immune patterns and potential treatment-related confounding.
resultsPatients with SLE exhibited a decreased proportion of helper T (Th) cells and an increased percentage of cytotoxic T (Tc) cells compared with HC, accompanied by a reduced CD4/CD8 ratio. The percentages of CD4
conclusionsPatients with SLE with renal involvement show coordinated disturbances in T-cell and B-cell compartments linked to chronic immune activation, interferon-related responses and disease duration. These findings support the relevance of integrated immune profiling in SLE but should be interpreted as exploratory and require validation in larger longitudinal cohorts.
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