Evidence map›Paper›PMID 42457333›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2026

[Role of miR-146b-5p in hyperoxia-induced pulmonary vascular remodeling in neonatal rats: mechanisms based on the regulation of ferroptosis].

Wei Wang, Ting Zhao, Yan-Mei Wang, Ou Xie, Le Wang

Abstract readEnglish Abstract
In one paragraph

Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Wei WangDepartment of Neonatology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Ting Zhao
Yan-Mei Wang
Ou XieDepartment of Neonatology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Le Wang

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the role and mechanism of miR-146b-5p in pulmonary vascular remodeling in neonatal rats with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) induced by hyperoxia.

methodsThirty-two Sprague-Dawley neonatal rats were randomly assigned to normoxia group, BPD-PH group, overexpression group, and inhibitor group (

resultsCompared with the normoxia group, the BPD-PH group showed significantly increased RVSP, RVHI, MT%, and MA% (

conclusionsOverexpression of miR-146b-5p promotes pulmonary vascular remodeling in neonatal rats exposed to hyperoxia, likely through inhibition of the Nrf2/GPX4 signaling pathway and regulation of ferroptosis.

Indexed as

FerroptosisHyperoxiaHypertension, PulmonaryMicroRNAsVascular RemodelingAnimalsAnimals, NewbornBronchopulmonary DysplasiaLungPulmonary ArteryRatsRats, Sprague-DawleyMicroRNAsMIRN146 microRNA, ratBronchopulmonary dysplasia-associated pulmonary hypertensionFerroptosismiR-146b-5pNeonatal ratPulmonary vascular remodeling

Identifiers

PMID42457333
PMCPMC13372553

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.