Evidence map›Paper›PMID 42456816›Full record

ArticleJournal of affective disorders2026

Sadness regulation in daily life in remitted depression: Regulatory repertoire composition and affect-dependent effectiveness.

Srinidhi Jayakumar, Ellie P Xu, Sean A Minns, Sarah L Zapetis, Margarid R Turnamian, Jiani Li, Mengzhe Wei, Christine A Leonards, Archita Tharanipathy, Desiree E Webb and 1 more

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In one paragraph

Article in Journal of affective disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Srinidhi JayakumarDepartment of Psychology, University of Southern California, CA, 90007, USA.
Ellie P XuDepartment of Psychology, University of Southern California, CA, 90007, USA.
Sean A MinnsDepartment of Psychology, University of Southern California, CA, 90007, USA.
Sarah L ZapetisDepartment of Psychology, University of Southern California, CA, 90007, USA.
Margarid R TurnamianDepartment of Psychology, University of Southern California, CA, 90007, USA.
Jiani LiDepartment of Psychology, University of Southern California, CA, 90007, USA.
Mengzhe WeiDepartment of Psychology, University of Southern California, CA, 90007, USA.
Christine A LeonardsDepartment of Psychology, University of Southern California, CA, 90007, USA.
Archita TharanipathyDepartment of Psychology, University of Southern California, CA, 90007, USA.
Desiree E WebbDepartment of Psychology, University of Southern California, CA, 90007, USA.
Jonathan P StangeDepartment of Psychology, University of Southern California, United States; Department of Psychiatry and Behavioral Sciences, University of Southern California, United States. Electronic address: jstange@usc.edu.

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Ambulatory phenotyping with real-time indices of discordant affect regulation: Exploring opportunities for targeted intervention in depressionR01MH133842 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jonathan P Stange · 2023 to 2026
$3.0M
From Networks to the Real World: Integrating Neural and Autonomic Processes of LossK23MH112769 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI STANGE, JONATHAN P · 2017 to 2021
$931k
NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855NCATS NIH HHS UL1 TR002003NIMH NIH HHS K23 MH112769NIMH NIH HHS R01 MH133842
6 · The paper itself

Abstract

backgroundEmotion regulation (ER) vulnerabilities that confer risk for depression and persist into remission remain poorly understood. Prior work in depression has primarily examined ER strategies independently, leaving unclear how much each strategy is used within an individual's regulatory repertoire (relative strategy use). We examined whether individuals with remitted depression (rMDD) differ from never-depressed healthy comparisons (HC) in relative strategy use and whether sadness mediates these differences. We also explored whether strategy effectiveness is attenuated in rMDD, particularly in moments of elevated sadness in daily life.

method86 young adults with rMDD and HC completed 7-day ecological momentary assessments (3×/day) of sadness and ER strategy use. Relative strategy use was calculated as each strategy's proportion of an individual's total strategy use across the week.

resultsRelative to HC, individuals with rMDD utilized a greater proportion of distraction and a lower proportion of reappraisal. Elevated sadness in individuals with rMDD mediated lower reappraisal proportional use. During moments of greater-than-usual sadness, distraction and reappraisal use predicted lower subsequent sadness in HC, whereas distraction predicted greater subsequent sadness in rMDD. Rumination exacerbated sadness for both groups, with stronger effects in rMDD under high sadness.

conclusionResults suggest a skewed ER portfolio in remitted depression characterized by a greater proportion of distraction and a lower proportion of reappraisal. Further, when individuals with rMDD experience elevated sadness, distraction becomes counterproductive and reappraisal provides no benefit. Findings suggest relative strategy use and affect-contingent strategy implementation may be useful targets for improving ER effectiveness and preventing recurrence.

Indexed as

AffectDepressionEmotional RegulationMajor Depressive DisorderSadnessAdultCoping SkillsEcological Momentary AssessmentFemaleHumansMaleYoung AdultEmotion regulationEmotion regulation mixRegulatory repertoireRemitted depressionStrategy effectiveness

Identifiers

PMID42456816
PMCPMC13378438

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.