Evidence map›Paper›PMID 42456306›Full record

ArticleClinical practice and cases in emergency medicine2025

Intravenous Low-dose Buprenorphine for Acute Pain Management in the Emergency Department: A Case Series.

Jonathan Lee, Nicholas Ashenburg, Joshua Park, Terence Ahern

Abstract readCase Reports
In one paragraph

Article in Clinical practice and cases in emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jonathan LeeStanford University School of Medicine, Department of Anesthesiology, Perioperative, and Pain Medicine, Palo Alto, California.
Nicholas AshenburgStanford University School of Medicine, Department of Emergency Medicine, Palo Alto, California.
Joshua ParkStanford Health Care, Department of Pharmacy, Palo Alto, California.
Terence AhernStanford University School of Medicine, Department of Emergency Medicine, Palo Alto, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBuprenorphine is used for treating opioid use disorder, but its role as an analgesic in the emergency department (ED) is frequently overlooked. Emerging evidence indicates that, at low doses, it can be used safely and advantageously as an alternative to full-agonist opioids for treating acute pain. CASE SERIES: This case series examines the novel use of intravenous (IV) low-dose buprenorphine for acute pain management in the ED for five patients presenting with diverse past medical history and varied painful indications.

conclusionIntravenous low-dose buprenorphine may represent an important new tool in our ED armamentarium, and research into its role in emergency pain management is warranted. Further work is needed to determine optimal dosing strategies and identify which patients will be most likely to benefit from IV low-dosebuprenorphine in the ED.

Identifiers

PMID42456306
PMCPMC12342646

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.