Evidence map›Paper›PMID 42455974›Full record

ArticleEndocrinology, diabetes & metabolism case reports2026

Osteoporosis associated with pregnancy and lactation (PLO): can REMS have a role in prevention and follow-up?

Antonella Al Refaie, Caterina Mondillo, Leonardo Baldassini, Roberto Tarquini, Luigi Gennari, Stefano Gonnelli, Carla Caffarelli

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Article in Endocrinology, diabetes & metabolism case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Antonella Al RefaieSection of Internal Medicine, Department of Medicine, Surgery and Neuroscience, University of Siena , Siena, Italy.ORCID 0009-0004-2019-5703
Caterina MondilloSection of Internal Medicine, Department of Medicine, Surgery and Neuroscience, University of Siena , Siena, Italy.
Leonardo BaldassiniSection of Internal Medicine, Department of Medicine, Surgery and Neuroscience, University of Siena , Siena, Italy.
Roberto TarquiniDivision of Internal Medicine I, San Giuseppe Hospital , Empoli, Italy.
Luigi GennariSection of Internal Medicine, Department of Medicine, Surgery and Neuroscience, University of Siena , Siena, Italy.
Stefano GonnelliSection of Internal Medicine, Department of Medicine, Surgery and Neuroscience, University of Siena , Siena, Italy.
Carla CaffarelliSection of Internal Medicine, Department of Medicine, Surgery and Neuroscience, University of Siena , Siena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

summaryOsteoporosis associated with pregnancy and lactation (PLO) is a debilitating premenopausal osteoporosis that occurs during the last trimester of pregnancy or breastfeeding. Its pathogenesis is complex and remains unclear, and there are currently no established guidelines. Case reports are valuable for clinicians in diagnosis, management, and treatment. We report a case of a young woman with multiple vertebral fractures who received a diagnosis of PLO. The patient was treated with vitamin D, teriparatide, and lifestyle modifications. We monitored the patient's bone mineral density using radiofrequency echographic multi-spectrometry (REMS) technology, a novel ultrasound tool for bone status evaluation. The ability to follow up young patients at risk of PLO using this safe, non-ionizing radiation tool could represent a significant advancement in the management of this condition. LEARNING POINTS:

Indexed as

lactationosteoporosis associated with pregnancy and lactationPLOpregnancyREMS

Identifiers

PMID42455974
PMCPMC13389467

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.