ArticleScience advances2026
Satellite DNA sequence dictates pericentromere heterochromatin formation and function.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Cross-species incompatibilities offer new insights into the functional consequences of satellite DNA evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026Review
- Repeat offenders: Satellite DNA sequence variation drives heterochromatin instability.Science advances · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Pericentromeres are heterochromatic regions adjacent to centromeres that ensure accurate chromosome segregation. Despite their conserved function, they are composed of rapidly evolving A/T-rich satellite DNA. To test the functional consequences of this rapid sequence evolution, we establish hybrid mouse embryos as a model system to compare divergent satellite arrays from distinct species in a common cytoplasm. We show that variation in satellite sequence impacts heterochromatin formation, recruitment of the Chromosome Passenger Complex (CPC), and interactions with the mitotic spindle. Differences in satellite DNA sequence alter pericentromere packaging by Polycomb Repressive Complex 1 (PRC1), as satellite arrays that recruit PRC1 are enriched for specific A/T sequences that the PRC1 AT-hook preferentially binds. Furthermore, PRC1 heterochromatin modifies pericentromere function by inhibiting recruitment of the CPC, increasing microtubule forces on kinetochores during mitosis. Our results provide a direct link between satellite DNA composition and mitotic chromosome behavior and highlight early embryogenesis as a critical point in development that is sensitive to satellite DNA evolution.
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Registered trials
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