Evidence map›Paper›PMID 42455952›Full record

ArticleScience advances2026

Efficient chemical reprogramming of human T cells into functional megakaryocytes and platelets.

Jinhua Qin, Zheng Hua, Xingxing Zhao, Jianan Jiang, Jisheng Li, Sihan Wang, Yingwei Pan, Bowen Zhang, Yunqiao Li, Qianqian Zhou and 10 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jinhua QinBeijing Institute of Radiation Medicine, Beijing 100850, China.ORCID 0000-0002-6800-2761
Zheng HuaBeijing Institute of Radiation Medicine, Beijing 100850, China.
Xingxing ZhaoBeijing Institute of Radiation Medicine, Beijing 100850, China.
Jianan JiangBeijing Institute of Radiation Medicine, Beijing 100850, China.
Jisheng LiBeijing Institute of Radiation Medicine, Beijing 100850, China.ORCID 0000-0001-9109-5815
Sihan WangBeijing Institute of Radiation Medicine, Beijing 100850, China.ORCID 0000-0003-3012-1674
Yingwei PanBeijing Institute of Radiation Medicine, Beijing 100850, China.ORCID 0000-0002-5852-8727
Bowen ZhangBeijing Institute of Radiation Medicine, Beijing 100850, China.
Yunqiao LiBeijing Institute of Radiation Medicine, Beijing 100850, China.
Qianqian ZhouInstitute of Health Service and Transfusion Medicine, Beijing 100850, China.
Yiming ZhangBeijing Institute of Radiation Medicine, Beijing 100850, China.
Yanzhou ChenBeijing Institute of Radiation Medicine, Beijing 100850, China.
Yiming LiuBeijing Institute of Radiation Medicine, Beijing 100850, China.
Caiping XuBeijing Institute of Radiation Medicine, Beijing 100850, China.
Tao FanBeijing Institute of Radiation Medicine, Beijing 100850, China.
Yang LvBeijing Institute of Radiation Medicine, Beijing 100850, China.
Xinlong YanCollege of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China.ORCID 0000-0001-9967-5654
Wen YueBeijing Institute of Radiation Medicine, Beijing 100850, China.ORCID 0000-0002-3935-360X
Xuetao PeiBeijing Institute of Radiation Medicine, Beijing 100850, China.ORCID 0000-0001-7717-3434
Yanhua LiBeijing Institute of Radiation Medicine, Beijing 100850, China.ORCID 0000-0001-5584-9376

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The generation of megakaryocytes (MKs) from human somatic cells through chemical reprogramming represents a promising strategy for developing alternative platelet sources. Building on our prior chemical reprogramming protocol for converting erythroblasts to MKs, we established a robust method that successfully generated induced MKs (iMKs) from human cord blood-derived CD3

Indexed as

Blood PlateletsCellular ReprogrammingMegakaryocytesT-LymphocytesCell DifferentiationHumans

Identifiers

PMID42455952
PMCPMC13371930

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.