Evidence map›Paper›PMID 42455915›Full record

ArticleScience advances2026

Functional segregation in Parkinson's disease.

Dongning Su, Jordan U Hanania, Alexandra Pavel, Connor Bevington, Jessie Fanglu Fu, Michele Matarazzo, Ju-Chieh Kevin Cheng, Jessamyn McKenzie, Elham Shahinfard, Nasim Vafai and 7 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Dongning SuCenter for Movement Disorders, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-3609-4224
Jordan U HananiaDepartment of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada.
Alexandra PavelDjavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.
Connor BevingtonDepartment of Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-6258-8450
Jessie Fanglu FuAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.ORCID 0000-0002-4970-7811
Michele MatarazzoDjavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.ORCID 0000-0002-2907-8667
Ju-Chieh Kevin ChengDjavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.ORCID 0000-0002-8834-3547
Jessamyn McKenzieDjavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.ORCID 0000-0001-6835-8867
Elham ShahinfardDjavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.ORCID 0000-0002-3526-0086
Nasim VafaiDjavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.
Sahib DhaliwalDjavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.ORCID 0009-0001-4404-9135
Qing MiaoTRIUMF, Vancouver, BC, Canada.ORCID 0009-0006-1434-3858
Jeremy SeamansDepartment of Psychiatry, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Carolyn EnglishDjavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.
Ellen ChenDjavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.
Vesna SossiDjavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.ORCID 0000-0001-7862-5711
A Jon StoesslDjavad Mowafaghian Centre for Brain Health, Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health, Vancouver, BC, Canada.ORCID 0000-0002-9778-7246

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The basal ganglia are characterized by somatotopic representation and are organized in parallel, functionally segregated corticostriatal circuits, but the impact of Parkinson's disease (PD) on this architecture is unknown. We mapped task-evoked dopamine release using [

Indexed as

Parkinson DiseaseAgedBasal GangliaBrain MappingDopamineDopaminergic ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyDopamine

Identifiers

PMID42455915
PMCPMC13371900

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.